Detailed information of TA system TA144044

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 252183..253930
• Replicon: chromosome
• Accession: NZ_CP046344
• Organism: Burkholderia multivorans strain FDAARGOS_722

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: FOC30_RS01065
• Protein ID: WP_155820774.1
• Coordinates: 253034..253930 (-)
• Length: 299 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: FOC30_RS01060
• Protein ID: WP_048804599.1
• Coordinates: 252183..253037 (-)
• Length: 285 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC30_RS01040	247338..248828	-	1491	WP_043278809.1	aldehyde dehydrogenase	-
FOC30_RS01045	248906..249736	-	831	WP_006396783.1	aspartate dehydrogenase	-
FOC30_RS01050	249729..251396	-	1668	WP_155820773.1	thiamine pyrophosphate-binding protein	-
FOC30_RS01055	251389..252186	-	798	WP_059843037.1	SDR family oxidoreductase	-
FOC30_RS01060	252183..253037	-	855	WP_048804599.1	IclR family transcriptional regulator	Antitoxin
FOC30_RS01065	253034..253930	-	897	WP_155820774.1	alpha/beta fold hydrolase	Toxin
FOC30_RS01070	253949..254476	-	528	WP_006396778.1	cupin domain-containing protein	-
FOC30_RS01075	254504..255274	-	771	WP_155820775.1	SDR family oxidoreductase	-
FOC30_RS01080	255267..256337	-	1071	WP_155820776.1	aromatic ring-hydroxylating dioxygenase subunit alpha	-
FOC30_RS01085	256385..256696	-	312	WP_006396775.1	hypothetical protein	-
FOC30_RS01090	256698..257015	-	318	WP_006396774.1	non-heme iron oxygenase ferredoxin subunit	-
FOC30_RS01095	257452..258531	+	1080	WP_006413812.1	porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (51-280)

Antitoxin

• Transcription regulator IclR, N-terminal (23-71)

Sequences

Toxin

Protein

• Length: 299 a.a.
• Molecular weight: 30657.87 Da
• Isoelectric Point: 7.7124

>T144044 WP_155820774.1 NZ_CP046344:c253930-253034 [Burkholderia multivorans]
MSVVDKRERDRTAAFATLLERFPEQRCASDAAGTIGYREAGAQHAGAALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDTFCRQCDIERRAA

Nucleotide

• Length: 897 bp

>T144044 NZ_CP061681:459648-460037 [Acinetobacter seifertii]
TTGATCAACCAATTGAATTTTAAACTGAAATATAGCCGTTTCGCGATTGTATTTCAGTTTTTTATTGGCCTATGTTTAGC
AGCTCTGTTTTATCAGCTGATACCAATACTCTGGTGGTTGGTTACGCTCTGTTTATTATTTATAAGTTTTATTTTCTTTT
TAAAGCGACCACAGCTCGTTCAAATTGCCTATTTAGATCAGAAATTATGGTCTCTTAGCTTTCATTCAGAACAAACCATT
TCTCGTGTAGAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGGTCTATTTTAAGGGTGATAAAACATTAACTTC
TGTTATTTGGTTTGATCAAATGTCCTTATCTCAATGGAAACAGCTTAAGACTTTAGAAAAATTCTATTAA

Antitoxin

Protein

• Length: 285 a.a.
• Molecular weight: 31118.71 Da
• Isoelectric Point: 6.9856

>AT144044 WP_048804599.1 NZ_CP046344:c253037-252183 [Burkholderia multivorans]
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDALRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR

Nucleotide

• Length: 855 bp

>AT144044 NZ_CP061681:459396-459641 [Acinetobacter seifertii]
ATGACCTTGGAAGAACGTAAAGTAGTTTATCGCGCACGCCGCGGTTTAAAGGAAATTGATGTCTATTTTGACCCGTATGT
GAAAAATTATTATTTAAAGGCAGATCCAGCAGAAAAAGCATTGTTTGCTGAATTAGTAGAGCAGGAAGATCCTGATTTAC
TTGACTGGTTTATGGAAGTATCTGAACCGCCGCGTACAGAATTACGTGATTTTATTCATAAATTAAAGCATTATGTTCAT
GGCTGA