Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/Tad-HTH_37
Location 2444178..2444878 Replicon chromosome
Accession NZ_CP046343
Organism Burkholderia multivorans strain FDAARGOS_726

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag FOC34_RS25310 Protein ID WP_155819766.1
Coordinates 2444501..2444878 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag FOC34_RS25305 Protein ID WP_059787265.1
Coordinates 2444178..2444501 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC34_RS25285 2439526..2440986 + 1461 WP_155819760.1 PLP-dependent aminotransferase family protein -
FOC34_RS25290 2441146..2443044 + 1899 WP_039219510.1 molecular chaperone HtpG -
FOC34_RS25295 2443053..2443667 + 615 WP_006398690.1 chorismate lyase -
FOC34_RS25300 2443664..2444155 + 492 WP_155819763.1 DNA-deoxyinosine glycosylase -
FOC34_RS25305 2444178..2444501 - 324 WP_059787265.1 helix-turn-helix domain-containing protein Antitoxin
FOC34_RS25310 2444501..2444878 - 378 WP_155819766.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOC34_RS25315 2445410..2445664 - 255 WP_035951935.1 hypothetical protein -
FOC34_RS25320 2445893..2446810 + 918 WP_059787259.1 hypothetical protein -
FOC34_RS25325 2447007..2447240 + 234 WP_006398697.1 DUF3311 domain-containing protein -
FOC34_RS25330 2447237..2448787 + 1551 WP_006398698.1 sodium:solute symporter family protein -
FOC34_RS25335 2448891..2449340 - 450 WP_006413500.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(22-114)

Antitoxin

Cro/C1-type helix-turn-helix domain

(30-85)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13435.42 Da        Isoelectric Point: 9.5721

>T144043 WP_155819766.1 NZ_CP046343:c2444878-2444501 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKDLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLSGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGGK

Download         Length: 378 bp

>T144043 NZ_CP061679:c47566-47210 [Acinetobacter seifertii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGACCTACGTGTTCAGCATCGAGGTAAATCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGTGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11798.66 Da        Isoelectric Point: 8.0686

>AT144043 WP_059787265.1 NZ_CP046343:c2444501-2444178 [Burkholderia multivorans]
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSEAEGHIEVVFAA

Download         Length: 324 bp

>AT144043 NZ_CP061679:c47217-46915 [Acinetobacter seifertii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References