Detailed information of TA system TA144042

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 1435764..1436401
• Replicon: chromosome
• Accession: NZ_CP046343
• Organism: Burkholderia multivorans strain FDAARGOS_726

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FOC34_RS20570
• Protein ID: WP_155819369.1
• Coordinates: 1435764..1436165 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: J5BG47
• Locus tag: FOC34_RS20575
• Protein ID: WP_006415629.1
• Coordinates: 1436165..1436401 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC34_RS20560	1433095..1434237	+	1143	WP_155819368.1	alginate lyase family protein	-
FOC34_RS20565	1434264..1435652	+	1389	WP_006408285.1	L-serine ammonia-lyase	-
FOC34_RS20570	1435764..1436165	-	402	WP_155819369.1	type II toxin-antitoxin system VapC family toxin	Toxin
FOC34_RS20575	1436165..1436401	-	237	WP_006415629.1	hypothetical protein	Antitoxin
FOC34_RS20580	1436589..1438292	+	1704	WP_105757836.1	thiamine pyrophosphate-binding protein	-
FOC34_RS20585	1438289..1439377	+	1089	WP_155819370.1	ADP-heptose--LPS heptosyltransferase	-
FOC34_RS20590	1439505..1440536	-	1032	WP_155819371.1	helix-turn-helix domain-containing protein	-
FOC34_RS20595	1440700..1441242	-	543	WP_059875692.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-116)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14872.07 Da
• Isoelectric Point: 6.7035

>T144042 WP_155819369.1 NZ_CP046343:c1436165-1435764 [Burkholderia multivorans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELAYGVTVCANPARERRNLAALIEDIPVAPFDGAAAQA
YGPIREATRERKKDHLDKLIGAHAVSLDVVLVTNHERDFAGYPGLRLENWLTG

Nucleotide

• Length: 402 bp

>T144042 NZ_CP061678:460942-461331 [Acinetobacter seifertii]
TTGATCAACCAATTGAATTTTAAACTGAAATATAGCCGTTTCGCGATTGTATTTCAGTTTTTTATTGGCCTATGTTTAGC
AGCTCTGTTTTATCAGCTGATACCAATACTCTGGTGGTTGGTTACGCTCTGTTTATTATTTATAAGTTTTATTTTCTTTT
TAAAGCGACCACAGCTCGTTCAAATTGCCTATTTAGATCAGAAATTATGGTCTCTTAGCTTTCATTCAGAACAAACCATT
TCTCGTGTAGAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGGTCTATTTTAAGGGTGATAAAACATTAACTTC
TGTTATTTGGTTTGATCAAATGTCCTTATCTCAATGGAAACAGCTTAAGACTTTAGAAAAATTCTATTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8973.04 Da
• Isoelectric Point: 5.1651

>AT144042 WP_006415629.1 NZ_CP046343:c1436401-1436165 [Burkholderia multivorans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPARRPLTGVLGKFAKFGPDFMAEGRGDQEQAEREDW

Nucleotide

• Length: 237 bp

>AT144042 NZ_CP061678:460690-460935 [Acinetobacter seifertii]
ATGACCTTGGAAGAACGTAAAGTAGTTTATCGCGCACGCCGCGGTTTAAAGGAAATTGATGTCTATTTTGACCCGTATGT
GAAAAATTATTATTTAAAGGCAGATCCAGCAGAAAAAGCATTGTTTGCTGAATTAGTAGAGCAGGAAGATCCTGATTTAC
TTGACTGGTTTATGGAAGTATCTGAACCGCCGCGTACAGAATTACGTGATTTTATTCATAAATTAAAGCATTATGTTCAT
GGCTGA

Structures

Antitoxin

• AlphaFold DB: J5BG47