Detailed information of TA system TA144041

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 70911..71495
• Replicon: chromosome
• Accession: NZ_CP046343
• Organism: Burkholderia multivorans strain FDAARGOS_726

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FOC34_RS14195
• Protein ID: WP_155818813.1
• Coordinates: 70911..71207 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: J4SGI3
• Locus tag: FOC34_RS14200
• Protein ID: WP_006409266.1
• Coordinates: 71211..71495 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC34_RS14175	66423..67523	-	1101	WP_155818812.1	chorismate synthase	-
FOC34_RS14180	67692..69626	-	1935	WP_059782304.1	MFS transporter	-
FOC34_RS14185	69772..70227	-	456	WP_006402096.1	CBS domain-containing protein	-
FOC34_RS14190	70388..70705	+	318	WP_006402097.1	DUF962 domain-containing protein	-
FOC34_RS14195	70911..71207	+	297	WP_155818813.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FOC34_RS14200	71211..71495	+	285	WP_006409266.1	putative addiction module antidote protein	Antitoxin
FOC34_RS14205	71579..71767	+	189	WP_060111233.1	hypothetical protein	-
FOC34_RS14210	71934..73262	-	1329	WP_039224705.1	YihY family inner membrane protein	-
FOC34_RS14215	73407..74018	+	612	WP_006402099.1	NAD(P)H:quinone oxidoreductase	-
FOC34_RS14220	74015..74410	+	396	WP_088926186.1	DUF2069 domain-containing protein	-
FOC34_RS14225	74429..75850	+	1422	WP_012467582.1	FAD-binding oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-97)

Antitoxin

• Uncharacterized protein HI1420 (5-90)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11171.88 Da
• Isoelectric Point: 9.4615

>T144041 WP_155818813.1 NZ_CP046343:70911-71207 [Burkholderia multivorans]
MVTLLRSTEFNDWLANLRDQRGKARIAARLISAQLGNFGEYGVLDEGVCELKIDFGPGYRVYYVRRGEVVYLLLCGGDKS
TQRKDIKRAAQMARELKE

Nucleotide

• Length: 297 bp

>T144041 NZ_CP061677:64652-65011 [Acinetobacter seifertii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 9986.38 Da
• Isoelectric Point: 6.2121

>AT144041 WP_006409266.1 NZ_CP046343:71211-71495 [Burkholderia multivorans]
MTNYTEFDAADYLDNDEAVAEFLAVAAEDPNPDVFLAAVAAVARARGMTKVAAAAGVGRVALHKALTPGAHPRYETVQKI
IRSLGLRMSFTVAH

Nucleotide

• Length: 285 bp

>AT144041 NZ_CP061677:65011-65310 [Acinetobacter seifertii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Structures

Antitoxin

• AlphaFold DB: J4SGI3