Detailed information of TA system TA144040

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 2216881..2218180
• Replicon: chromosome
• Accession: NZ_CP046341
• Organism: Burkholderia multivorans strain FDAARGOS_726

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FOC34_RS09665
• Protein ID: WP_155817882.1
• Coordinates: 2217569..2218180 (+)
• Length: 204 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FOC34_RS09660
• Protein ID: WP_123789612.1
• Coordinates: 2216881..2217438 (+)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC34_RS09645	2213223..2213855	+	633	WP_105951288.1	cysteine hydrolase	-
FOC34_RS09650	2213894..2214625	-	732	WP_155817881.1	ribonuclease T2	-
FOC34_RS09655	2214965..2216367	-	1403	Protein_1914	DUF308 domain-containing protein	-
FOC34_RS09660	2216881..2217438	+	558	WP_123789612.1	helix-turn-helix domain-containing protein	Antitoxin
FOC34_RS09665	2217569..2218180	+	612	WP_155817882.1	HD domain-containing protein	Toxin
FOC34_RS09670	2218242..2219780	-	1539	WP_155817883.1	MFS transporter	-
FOC34_RS09675	2219959..2220879	+	921	WP_006406123.1	LysR family transcriptional regulator	-
FOC34_RS09680	2220932..2222071	-	1140	WP_155817884.1	enoyl-CoA hydratase/isomerase family protein	-
FOC34_RS09685	2222068..2222859	-	792	WP_155817885.1	enoyl-CoA hydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (6-185)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 204 a.a.
• Molecular weight: 22649.46 Da
• Isoelectric Point: 6.0800

>T144040 WP_155817882.1 NZ_CP046341:2217569-2218180 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
ATEQAAHPDKNMHERDDLLTLTAAIDPVLRNELVALWDEYDTAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLGY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQARTSSQTQTHTHRP

Nucleotide

• Length: 612 bp

>T144040 NZ_CP061676:c54887-54531 [Acinetobacter seifertii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGACCTACGTGTTCAGCATCGAGGTAAATCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGTGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20339.31 Da
• Isoelectric Point: 8.5490

>AT144040 WP_123789612.1 NZ_CP046341:2216881-2217438 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAALFGVAQSTISRWEAGVQQMSPDERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLSMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT144040 NZ_CP061676:c54538-54236 [Acinetobacter seifertii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA