Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2054867..2055558 Replicon chromosome
Accession NZ_CP046341
Organism Burkholderia multivorans strain FDAARGOS_726

Toxin (Protein)


Gene name vapC Uniprot ID B9AZ67
Locus tag FOC34_RS09010 Protein ID WP_006396652.1
Coordinates 2054867..2055322 (-) Length 152 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A132F1C7
Locus tag FOC34_RS09015 Protein ID WP_012216644.1
Coordinates 2055319..2055558 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC34_RS08990 2051302..2052252 + 951 WP_155817829.1 DMT family transporter -
FOC34_RS08995 2052440..2053015 + 576 WP_105841566.1 permease -
FOC34_RS09000 2053108..2053242 - 135 WP_006396654.1 entericidin A/B family lipoprotein -
FOC34_RS09005 2053475..2054770 + 1296 WP_012216646.1 aspartate carbamoyltransferase -
FOC34_RS09010 2054867..2055322 - 456 WP_006396652.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC34_RS09015 2055319..2055558 - 240 WP_012216644.1 Arc family DNA-binding protein Antitoxin
FOC34_RS09020 2055863..2058109 + 2247 WP_155817830.1 TonB-dependent siderophore receptor -
FOC34_RS09025 2058113..2058868 + 756 WP_105777242.1 sel1 repeat family protein -
FOC34_RS09030 2058865..2059548 + 684 WP_006396647.1 Fe2+-dependent dioxygenase -
FOC34_RS09035 2059562..2059765 - 204 WP_155817831.1 hypothetical protein -
FOC34_RS09040 2060362..2060505 + 144 WP_006409932.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 152 a.a.        Molecular weight: 16267.60 Da        Isoelectric Point: 6.4793

>T144039 WP_006396652.1 NZ_CP046341:c2055322-2054867 [Burkholderia multivorans]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLEQSIEHRVVPVFRGRILPFDD
AASKAYARIRAHARAGGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWASQGAPVRQGIASK

Download         Length: 456 bp

>T144039 NZ_CP061675:459771-460160 [Acinetobacter seifertii]
TTGATCAACCAATTGAATTTTAAACTGAAATATAGCCGTTTCGCGATTGTATTTCAGTTTTTTATTGGCCTATGTTTAGC
AGCTCTGTTTTATCAGCTGATACCAATACTCTGGTGGTTGGTTACGCTCTGTTTATTATTTATAAGTTTTATTTTCTTTT
TAAAGCGACCACAGCTCGTTCAAATTGCCTATTTAGATCAGAAATTATGGTCTCTTAGCTTTCATTCAGAACAAACCATT
TCTCGTGTAGAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGGTCTATTTTAAGGGTGATAAAACATTAACTTC
TGTTATTTGGTTTGATCAAATGTCCTTATCTCAATGGAAACAGCTTAAGACTTTAGAAAAATTCTATTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8716.94 Da        Isoelectric Point: 5.1133

>AT144039 WP_012216644.1 NZ_CP046341:c2055558-2055319 [Burkholderia multivorans]
MPVITVRNLPDEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTPTDPMSFE

Download         Length: 240 bp

>AT144039 NZ_CP061675:459519-459764 [Acinetobacter seifertii]
ATGACCTTGGAAGAACGTAAAGTAGTTTATCGCGCACGCCGCGGTTTAAAGGAAATTGATGTCTATTTTGACCCGTATGT
GAAAAATTATTATTTAAAGGCAGATCCAGCAGAAAAAGCATTGTTTGCTGAATTAGTAGAGCAGGAAGATCCTGATTTAC
TTGACTGGTTTATGGAAGTATCTGAACCGCCGCGTACAGAATTACGTGATTTTATTCATAAATTAAAGCATTATGTTCAT
GGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B9AZ67

Antitoxin

Source ID Structure
AlphaFold DB A0A132F1C7

References