Detailed information of TA system TA144038

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 1918996..1920743
• Replicon: chromosome
• Accession: NZ_CP046341
• Organism: Burkholderia multivorans strain FDAARGOS_726

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: FOC34_RS08385
• Protein ID: WP_155817765.1
• Coordinates: 1919847..1920743 (-)
• Length: 299 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: FOC34_RS08380
• Protein ID: WP_048804599.1
• Coordinates: 1918996..1919850 (-)
• Length: 285 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC34_RS08360	1914151..1915641	-	1491	WP_155817763.1	aldehyde dehydrogenase	-
FOC34_RS08365	1915719..1916549	-	831	WP_006396783.1	aspartate dehydrogenase	-
FOC34_RS08370	1916542..1918209	-	1668	WP_155817764.1	thiamine pyrophosphate-binding protein	-
FOC34_RS08375	1918202..1918999	-	798	WP_006396781.1	SDR family oxidoreductase	-
FOC34_RS08380	1918996..1919850	-	855	WP_048804599.1	IclR family transcriptional regulator	Antitoxin
FOC34_RS08385	1919847..1920743	-	897	WP_155817765.1	alpha/beta fold hydrolase	Toxin
FOC34_RS08390	1920762..1921289	-	528	WP_006396778.1	cupin domain-containing protein	-
FOC34_RS08395	1921317..1922087	-	771	WP_155817766.1	SDR family oxidoreductase	-
FOC34_RS08400	1922080..1923150	-	1071	WP_155817767.1	aromatic ring-hydroxylating dioxygenase subunit alpha	-
FOC34_RS08405	1923198..1923509	-	312	WP_155817768.1	hypothetical protein	-
FOC34_RS08410	1923511..1923828	-	318	WP_006396774.1	non-heme iron oxygenase ferredoxin subunit	-
FOC34_RS08415	1924264..1925343	+	1080	WP_039217461.1	porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (51-280)

Antitoxin

• Transcription regulator IclR, N-terminal (23-71)

Sequences

Toxin

Protein

• Length: 299 a.a.
• Molecular weight: 30613.86 Da
• Isoelectric Point: 8.0534

>T144038 WP_155817765.1 NZ_CP046341:c1920743-1919847 [Burkholderia multivorans]
MSVVDKRERDRTAAFATLLERFPEQRCAAGAAGTIGYREAGAQHAGAALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLVSPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLASDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDTFCRQCDIERRVA

Nucleotide

• Length: 897 bp

>T144038 NZ_CP061667:45493-45849 [Acinetobacter seifertii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGACCTACGTGTTCAGCATCGAGGTAAATCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGTGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Protein

• Length: 285 a.a.
• Molecular weight: 31118.71 Da
• Isoelectric Point: 6.9856

>AT144038 WP_048804599.1 NZ_CP046341:c1919850-1918996 [Burkholderia multivorans]
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDALRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR

Nucleotide

• Length: 855 bp

>AT144038 NZ_CP061667:45842-46144 [Acinetobacter seifertii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA