Detailed information of TA system TA144036

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1618872..1619406
• Replicon: chromosome
• Accession: NZ_CP046341
• Organism: Burkholderia multivorans strain FDAARGOS_726

Toxin (Protein)

• Gene name: parE
• Uniprot ID: B9B0C1
• Locus tag: FOC34_RS07195
• Protein ID: WP_006397059.1
• Coordinates: 1619107..1619406 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: B9B0C2
• Locus tag: FOC34_RS07190
• Protein ID: WP_006397060.1
• Coordinates: 1618872..1619117 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC34_RS07175	1613931..1615634	+	1704	WP_155817532.1	VRR-NUC domain-containing protein	-
FOC34_RS07180	1615631..1617931	+	2301	WP_155817534.1	ATP-dependent DNA helicase	-
FOC34_RS07185	1617962..1618732	-	771	WP_105781158.1	helix-turn-helix domain-containing protein	-
FOC34_RS07190	1618872..1619117	+	246	WP_006397060.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
FOC34_RS07195	1619107..1619406	+	300	WP_006397059.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FOC34_RS07200	1619515..1620816	-	1302	WP_006403538.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
FOC34_RS07205	1621041..1622348	-	1308	WP_060041937.1	shikimate transporter	-
FOC34_RS07210	1622702..1623829	+	1128	WP_155817536.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• Antitoxin ParD (1-80)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11586.09 Da
• Isoelectric Point: 7.3154

>T144036 WP_006397059.1 NZ_CP046341:1619107-1619406 [Burkholderia multivorans]
MPVKARTVRLTPLAEADLEAIWSYTYERWSLDQAERYIGELSAAFERLARRESVGWPSRAGGNYSRYLVGSHVVFYRETT
ETLDVIRVLHQRMDVDRHL

Nucleotide

• Length: 300 bp

>T144036 NZ_CP061664:497730-498119 [Acinetobacter seifertii]
TTGGTCAACCAATTGAATTTTAAACTGAAATATAGCCGTTTCTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTGTTTTATCAACTCCTACCAATACTCTGGTGGTTGGTTACGGTCAGTTTACTATTTATAAGTTTTGTTTTCTTTT
TAAAGCGACCACAGCTCGCTCAAATTGCTTATTTAGATCAGAAATTATGGTCACTTAGCTTTCATTCAGAACAAACCATT
TCTCGTGTAGAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGGCATAAAACATTAACTTC
TGTGATTTGGTTTGATCAAATGTCCTTATCTCAATGGAAAAAGCTTAAGACTTTAGAAAAATTCTATTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8662.73 Da
• Isoelectric Point: 6.4604

>AT144036 WP_006397060.1 NZ_CP046341:1618872-1619117 [Burkholderia multivorans]
MARNTSISLGDHLTEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGTPAPFDSQAFLARMRAKHA
G

Nucleotide

• Length: 246 bp

>AT144036 NZ_CP061664:497478-497723 [Acinetobacter seifertii]
ATGACCTTGGAAGAACGTAAAGTAGTTTATCGCGCACGCCGCGGTTTAAAGGAAATTGATGTCTATTTTGACCCGTATGT
GAAAAATTATTATTTAAAGGCAGATCCAGCAGAAAAAGCATTGTTTGCTGAATTAGTAGAGCAGGAAGATCCTGATTTAC
TTGACTGGTTTATGGAAGTATCTGAACCGCCGCGTACAGAATTACGTGATTTTATTCATAAATTAAAGCATTATGTTCAT
GGCTGA

Structures

Toxin

• AlphaFold DB: B9B0C1

Antitoxin

• AlphaFold DB: B9B0C2