Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relE-PumB/upstrm_HI1419-dnstrm_HI1420 |
Location | 838554..839174 | Replicon | chromosome |
Accession | NZ_CP046341 | ||
Organism | Burkholderia multivorans strain FDAARGOS_726 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A0H3KJN2 |
Locus tag | FOC34_RS03770 | Protein ID | WP_012217495.1 |
Coordinates | 838857..839174 (-) | Length | 106 a.a. |
Antitoxin (Protein)
Gene name | PumB | Uniprot ID | B9B269 |
Locus tag | FOC34_RS03765 | Protein ID | WP_006398012.1 |
Coordinates | 838554..838853 (-) | Length | 100 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FOC34_RS03740 | 833791..835062 | + | 1272 | WP_039225733.1 | Rieske 2Fe-2S domain-containing protein | - |
FOC34_RS03745 | 835077..835565 | + | 489 | WP_006398008.1 | aromatic-ring-hydroxylating dioxygenase subunit beta | - |
FOC34_RS03750 | 835583..835909 | + | 327 | WP_155817218.1 | non-heme iron oxygenase ferredoxin subunit | - |
FOC34_RS03755 | 835899..837119 | + | 1221 | WP_155817219.1 | FAD-dependent oxidoreductase | - |
FOC34_RS03760 | 837233..838519 | + | 1287 | WP_039225729.1 | DUF445 domain-containing protein | - |
FOC34_RS03765 | 838554..838853 | - | 300 | WP_006398012.1 | putative addiction module antidote protein | Antitoxin |
FOC34_RS03770 | 838857..839174 | - | 318 | WP_012217495.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
FOC34_RS03780 | 839537..841177 | + | 1641 | WP_006398015.1 | acetolactate synthase large subunit | - |
FOC34_RS03785 | 841206..842639 | + | 1434 | WP_059843122.1 | aldehyde dehydrogenase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12110.94 Da Isoelectric Point: 10.2349
>T144035 WP_012217495.1 NZ_CP046341:c839174-838857 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE
Download Length: 318 bp
>T144035 NZ_CP061662:c47590-47231 [Acinetobacter seifertii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA
Antitoxin
Download Length: 100 a.a. Molecular weight: 10605.00 Da Isoelectric Point: 6.6381
>AT144035 WP_006398012.1 NZ_CP046341:c838853-838554 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA
Download Length: 300 bp
>AT144035 NZ_CP061662:c47231-46932 [Acinetobacter seifertii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3KJN2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3KTI5 |