Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 838554..839174 Replicon chromosome
Accession NZ_CP046341
Organism Burkholderia multivorans strain FDAARGOS_726

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag FOC34_RS03770 Protein ID WP_012217495.1
Coordinates 838857..839174 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag FOC34_RS03765 Protein ID WP_006398012.1
Coordinates 838554..838853 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC34_RS03740 833791..835062 + 1272 WP_039225733.1 Rieske 2Fe-2S domain-containing protein -
FOC34_RS03745 835077..835565 + 489 WP_006398008.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
FOC34_RS03750 835583..835909 + 327 WP_155817218.1 non-heme iron oxygenase ferredoxin subunit -
FOC34_RS03755 835899..837119 + 1221 WP_155817219.1 FAD-dependent oxidoreductase -
FOC34_RS03760 837233..838519 + 1287 WP_039225729.1 DUF445 domain-containing protein -
FOC34_RS03765 838554..838853 - 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
FOC34_RS03770 838857..839174 - 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOC34_RS03780 839537..841177 + 1641 WP_006398015.1 acetolactate synthase large subunit -
FOC34_RS03785 841206..842639 + 1434 WP_059843122.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T144035 WP_012217495.1 NZ_CP046341:c839174-838857 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T144035 NZ_CP061662:c47590-47231 [Acinetobacter seifertii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT144035 WP_006398012.1 NZ_CP046341:c838853-838554 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT144035 NZ_CP061662:c47231-46932 [Acinetobacter seifertii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References