Detailed information of TA system TA144034

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 1763018..1763613
• Replicon: chromosome
• Accession: NZ_CP046337
• Organism: Burkholderia multivorans strain FDAARGOS_719

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: -
• Locus tag: FOC27_RS23835
• Protein ID: WP_105834886.1
• Coordinates: 1763263..1763613 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: B9B2F5
• Locus tag: FOC27_RS23830
• Protein ID: WP_006397258.1
• Coordinates: 1763018..1763269 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC27_RS23815	1758444..1759415	-	972	WP_155825412.1	LysR family transcriptional regulator	-
FOC27_RS23820	1759557..1760861	+	1305	WP_039222447.1	MFS transporter	-
FOC27_RS23825	1760962..1762455	+	1494	WP_155825414.1	M81 family metallopeptidase	-
FOC27_RS23830	1763018..1763269	+	252	WP_006397258.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FOC27_RS23835	1763263..1763613	+	351	WP_105834886.1	type II toxin-antitoxin system ChpB family toxin	Toxin
FOC27_RS23840	1763793..1765328	-	1536	WP_039223192.1	multidrug efflux transporter outer membrane subunit OpcM	-
FOC27_RS23845	1765339..1768524	-	3186	WP_105770400.1	multidrug efflux RND transporter permease subunit CeoB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12356.39 Da
• Isoelectric Point: 10.4367

>T144034 WP_105834886.1 NZ_CP046337:1763263-1763613 [Burkholderia multivorans]
MVKRVKFERGDIVRVSLNPTLGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGAGTATQGVALV
NMVRMLDLEARGARKVERAPVEVVEDALARLQTIIE

Nucleotide

• Length: 351 bp

>T144034 NZ_CP061661:c64780-64424 [Acinetobacter seifertii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGACCTACGTGTTCAGCATCGAGGTAAATCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGTGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9007.36 Da
• Isoelectric Point: 6.2420

>AT144034 WP_006397258.1 NZ_CP046337:1763018-1763269 [Burkholderia multivorans]
MELKIQKWGNSAAVRLPSVLLEQINATVGSSLSADVRPDGVLLTPARRKYSLDDLVAQCDTKAPFPADMAAWGEVKPVGR
EAW

Nucleotide

• Length: 252 bp

>AT144034 NZ_CP061661:c64431-64129 [Acinetobacter seifertii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA

Structures

Antitoxin

• AlphaFold DB: A0A132EKI4