Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 1431637..1432927 Replicon chromosome
Accession NZ_CP046337
Organism Burkholderia multivorans strain FDAARGOS_719

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FOC27_RS22385 Protein ID WP_155825295.1
Coordinates 1432316..1432927 (+) Length 204 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FOC27_RS22380 Protein ID WP_155825294.1
Coordinates 1431637..1432194 (+) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC27_RS22360 1426698..1427714 + 1017 WP_105777694.1 AraC family transcriptional regulator -
FOC27_RS22365 1427843..1428481 + 639 WP_111310988.1 cysteine hydrolase -
FOC27_RS22370 1428652..1429383 - 732 WP_060181351.1 ribonuclease T2 -
FOC27_RS22375 1429724..1431127 - 1404 WP_155825293.1 DUF308 domain-containing protein -
FOC27_RS22380 1431637..1432194 + 558 WP_155825294.1 helix-turn-helix domain-containing protein Antitoxin
FOC27_RS22385 1432316..1432927 + 612 WP_155825295.1 HD domain-containing protein Toxin
FOC27_RS22390 1432989..1434527 - 1539 WP_155825296.1 MFS transporter -
FOC27_RS22395 1434706..1435626 + 921 WP_006406123.1 LysR family transcriptional regulator -
FOC27_RS22400 1435673..1436812 - 1140 WP_035955456.1 enoyl-CoA hydratase/isomerase family protein -
FOC27_RS22405 1436809..1437600 - 792 WP_155825297.1 enoyl-CoA hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-172)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 204 a.a.        Molecular weight: 22575.38 Da        Isoelectric Point: 5.8329

>T144033 WP_155825295.1 NZ_CP046337:1432316-1432927 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
ATEQAAHPEKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHAQGANPPDFDYAFNLGY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQTSSQTQTHTHRP

Download         Length: 612 bp

>T144033 NZ_CP061660:c3647908-3647519 [Acinetobacter seifertii]
TTGATCAACCAATTGAATTTTAAACTGAAATATAGCCGTTTCGCGATTGTATTTCAGTTTTTTATTGGCCTATGTTTAGC
AGCTCTGTTTTATCAGCTGATACCAATACTCTGGTGGTTGGTTACGCTCTGTTTATTATTTATAAGTTTTATTTTCTTTT
TAAAGCGACCACAGCTCGTTCAAATTGCCTATTTAGATCAGAAATTATGGTCTCTTAGCTTTCATTCAGAACAAACCATT
TCTCGTGTAGAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGGTCTATTTTAAGGGTGATAAAACATTAACTTC
TGTTATTTGGTTTGATCAAATGTCCTTATCTCAATGGAAACAGCTTAAGACTTTAGAAAAATTCTATTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20339.27 Da        Isoelectric Point: 8.1900

>AT144033 WP_155825294.1 NZ_CP046337:1431637-1432194 [Burkholderia multivorans]
MPDSPLHTPPLGPQLNRWRLLHRVKQSHAAALFGVAQSTISRWEAGLQQMSPDERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLSMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Download         Length: 558 bp

>AT144033 NZ_CP061660:c3648160-3647915 [Acinetobacter seifertii]
ATGACCTTGGAAGAACGTAAAGTAGTTTATCGCGCACGCCGCGGTTTAAAGGAAATTGATGTCTATTTTGACCCGTATGT
GAAAAATTATTATTTAAAGGCAGATCCAGCAGAAAAAGCATTGTTTGCTGAATTAGTAGAGCAGGAAGATCCTGATTTAC
TTGACTGGTTTATGGAAGTATCTGAACCGCCGCGTACAGAATTACGTGATTTTATTCATAAATTAAAGCATTATGTTCAT
GGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References