144032

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1268357..1269048 Replicon chromosome
Accession NZ_CP046337
Organism Burkholderia multivorans strain FDAARGOS_719

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FOC27_RS21725 Protein ID WP_065496260.1
Coordinates 1268357..1268812 (-) Length 152 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FOC27_RS21730 Protein ID WP_155825238.1
Coordinates 1268809..1269048 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC27_RS21700 1263441..1264235 + 795 WP_155825235.1 AraC family transcriptional regulator -
FOC27_RS21705 1264790..1265740 + 951 WP_196775928.1 DMT family transporter -
FOC27_RS21710 1265928..1266503 + 576 WP_155825237.1 permease -
FOC27_RS21715 1266598..1266732 - 135 WP_006396654.1 entericidin A/B family lipoprotein -
FOC27_RS21720 1266965..1268260 + 1296 WP_035487510.1 aspartate carbamoyltransferase -
FOC27_RS21725 1268357..1268812 - 456 WP_065496260.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC27_RS21730 1268809..1269048 - 240 WP_155825238.1 Arc family DNA-binding protein Antitoxin
FOC27_RS21735 1269353..1271599 + 2247 WP_105809663.1 TonB-dependent siderophore receptor -
FOC27_RS21740 1271603..1272358 + 756 WP_155825239.1 sel1 repeat family protein -
FOC27_RS21745 1272355..1273038 + 684 WP_006396647.1 Fe2+-dependent dioxygenase -
FOC27_RS21750 1273052..1273255 - 204 WP_105825668.1 hypothetical protein -
FOC27_RS21755 1273845..1273988 + 144 WP_006409932.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 152 a.a.        Molecular weight: 16209.56 Da        Isoelectric Point: 7.2060

>T144032 WP_065496260.1 NZ_CP046337:c1268812-1268357 [Burkholderia multivorans]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLAQSIEHRVVPVFRGRILPFDD
AASKAYARIRAHARAGGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWASQGAPVRQGIASK

Download         Length: 456 bp

>T144032 NZ_CP061649:2735-3022 [Acinetobacter seifertii]
ATGGAACAGTATTTCGAATGGGATGAGGCAAAGAATCGAAAGAATCAGAAAAAGCACGATGTCTCTTTCGAAACAGCAAG
CCTTGTTTTTGAAGATCCACTGAGGATCTCAATCCAGGACAGACATACCGATGGTGAAGAACGTTGGCAAACCATTGGAA
AAGTAAAAGGCGTACTAATGCTCTTAGTAGCTCACACCATCTTTGATGAAGATGACTGTGAAATCATACGAATCATTAGT
GCAAGACAAGTAACTAAGGCGGAGCGAGATAGATATGAGCATGGTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8732.98 Da        Isoelectric Point: 5.1133

>AT144032 WP_155825238.1 NZ_CP046337:c1269048-1268809 [Burkholderia multivorans]
MPVITVRNLPDEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTLTDPMSFE

Download         Length: 240 bp

>AT144032 NZ_CP061649:3009-3323 [Acinetobacter seifertii]
ATGAGCATGGTTAGATACTCACGCAAAGAACTGAATGAAAAATTCAGCGACAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAGGGAACGGTTCCTGACGATCAGCTAGATCTCTCAGATATGCCTGAAATTACCGACTGGAGCAATGCTGTACGCC
ATAATCAATTCTATCGCCCAGTGAAGCAACAGACTTCCATTCGTTTAGATGCTGATGTACTTGCATGGTTTAAAGCTCAA
GGCAAAGGCTATCAAACACGAATGAATGAAATTTTGCGGGATGCTATGCTCAAAGAATTAAAAAATCATCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References