Detailed information of TA system TA144031

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 1140334..1142081
• Replicon: chromosome
• Accession: NZ_CP046337
• Organism: Burkholderia multivorans strain FDAARGOS_719

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: FOC27_RS21155
• Protein ID: WP_048804598.1
• Coordinates: 1141185..1142081 (-)
• Length: 299 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: B9AZJ2
• Locus tag: FOC27_RS21150
• Protein ID: WP_006396780.1
• Coordinates: 1140334..1141188 (-)
• Length: 285 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC27_RS21130	1135505..1136995	-	1491	WP_155825134.1	aldehyde dehydrogenase	-
FOC27_RS21135	1137057..1137887	-	831	WP_006396783.1	aspartate dehydrogenase	-
FOC27_RS21140	1137880..1139547	-	1668	WP_155825135.1	thiamine pyrophosphate-binding protein	-
FOC27_RS21145	1139540..1140337	-	798	WP_155825136.1	SDR family oxidoreductase	-
FOC27_RS21150	1140334..1141188	-	855	WP_006396780.1	IclR family transcriptional regulator	Antitoxin
FOC27_RS21155	1141185..1142081	-	897	WP_048804598.1	alpha/beta fold hydrolase	Toxin
FOC27_RS21160	1142100..1142627	-	528	WP_006396778.1	cupin domain-containing protein	-
FOC27_RS21165	1142655..1143425	-	771	WP_006413827.1	SDR family oxidoreductase	-
FOC27_RS21170	1143418..1144488	-	1071	WP_155825137.1	aromatic ring-hydroxylating dioxygenase subunit alpha	-
FOC27_RS21175	1144536..1144847	-	312	WP_006396775.1	hypothetical protein	-
FOC27_RS21180	1144849..1145166	-	318	WP_155825139.1	non-heme iron oxygenase ferredoxin subunit	-
FOC27_RS21185	1145602..1146681	+	1080	WP_039217461.1	porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (51-280)

Antitoxin

• Transcription regulator IclR, N-terminal (23-71)

Sequences

Toxin

Protein

• Length: 299 a.a.
• Molecular weight: 30583.83 Da
• Isoelectric Point: 8.0534

>T144031 WP_048804598.1 NZ_CP046337:c1142081-1141185 [Burkholderia multivorans]
MSVVDKRERDRTAAFATLLERFPEQRCAAGAAGTIGYREAGAQHAGAALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDTFCRQCDIERRAA

Nucleotide

• Length: 897 bp

>T144031 NZ_CP061647:87496-87684 [Acinetobacter seifertii]
ATGAGTAAAGGACTATTTGAGTTGCGCTTAAAATCTCAAGAAGGTATTGCTCGTGTTATGTATTGCACACTAGTCGGTAA
ACGCATTGTAATGCTCCATAGTTTTGTTAAGAAAACCCAAAAAACACCTAAGCAAGATCTAAACCTAGCACTTGACCGCA
TGAAAGAGGTGAAAAATGCGAACACATGA

Antitoxin

Protein

• Length: 285 a.a.
• Molecular weight: 31176.75 Da
• Isoelectric Point: 6.6558

>AT144031 WP_006396780.1 NZ_CP046337:c1141188-1140334 [Burkholderia multivorans]
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR

Nucleotide

• Length: 855 bp

>AT144031 NZ_CP061647:87671-87958 [Acinetobacter seifertii]
ATGCGAACACATGAAGAAATGAAAGCACTTGCATTATCTCGTTCAGCAGTGCGTACCGAATACGAACGAATTGAACGTGA
AGAAATGCCCTTGCTCGATATGGTACTTACTGCACTTCGAGAGGCAGGTCTATCCCAAGCGCAAATCGCAGAACGCATGG
GAACAAATGTACCTGCCGTTTCACGGCTAGAAAAAGCATTGATCACAGGCAAACCATCACCATCTATTGCCACATTGCAA
AAATATGCTGCGGCAATTGGTAAACATGTTGAAGTGCGTTTTGTCTAA

Structures

Antitoxin

• AlphaFold DB: B9AZJ2