Detailed information of TA system TA144029

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 839527..840061
• Replicon: chromosome
• Accession: NZ_CP046337
• Organism: Burkholderia multivorans strain FDAARGOS_719

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FOC27_RS19970
• Protein ID: WP_155825023.1
• Coordinates: 839762..840061 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: J4RB90
• Locus tag: FOC27_RS19965
• Protein ID: WP_006413656.1
• Coordinates: 839527..839772 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC27_RS19950	834586..836289	+	1704	WP_155825021.1	VRR-NUC domain-containing protein	-
FOC27_RS19955	836286..838586	+	2301	WP_155825022.1	ATP-dependent DNA helicase	-
FOC27_RS19960	838617..839387	-	771	WP_006403543.1	helix-turn-helix domain-containing protein	-
FOC27_RS19965	839527..839772	+	246	WP_006413656.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
FOC27_RS19970	839762..840061	+	300	WP_155825023.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FOC27_RS19975	840170..841471	-	1302	WP_006403538.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
FOC27_RS19980	841642..842370	+	729	WP_155825024.1	HNH endonuclease	-
FOC27_RS19985	842405..843712	-	1308	WP_155825025.1	shikimate transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• Antitoxin ParD (1-80)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11542.04 Da
• Isoelectric Point: 7.3154

>T144029 WP_155825023.1 NZ_CP046337:839762-840061 [Burkholderia multivorans]
MPVKARTVRLTPLAEADLEAIWAYTYERWSLDQAERYIGELSAAFERLARRESVGWPSRAGGNYSRYLVGSHVAFYRETT
ETLDVIRVLHQRMDVDRHL

Nucleotide

• Length: 300 bp

>T144029 NZ_CP061646:c3457642-3457253 [Acinetobacter seifertii]
TTGGTCAACCAATTGAATTTTAAACTGAAATATAGCCGTTTCTCGATTATATTTCAGTTTTTTATTGGCCTGGGTTTAGC
AGCTCTGTTTTATCAGTTGATACCAATACTCTGGTGGTTGGTTGCGGTCTGTTTATTATTTATAAGTTTTATTTTCTTTT
TAAAACGACCACAGCTTGCTCAAATTGCTTATTTAGATCAGAAATTATGGTCACTTAGCTTTCATTCAGAACAAACCATT
TCTCGTGTAGAAATTTTAAAAATAATTGATTATCAGATTTTCGTAGTGGTCTATTTTGAGGGTGATAAAACATTAACTTC
TGTTATTTGGTTTGATCAAATGTCCTTATCTCAATGGAAACAGCTTAAGACTTTAGAAAAATTCTATTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8632.71 Da
• Isoelectric Point: 6.4604

>AT144029 WP_006413656.1 NZ_CP046337:839527-839772 [Burkholderia multivorans]
MARNTSISLGDHLAEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGTPAPFDSQAFLARMRAKHA
G

Nucleotide

• Length: 246 bp

>AT144029 NZ_CP061646:c3457894-3457649 [Acinetobacter seifertii]
ATGACCTTGGAAGAACGTAAAGTAGTTTATCGCGCACGCCGCGGTTTAAAGGAAATTGATGTCTATTTTGACCCGTATGT
GAAAAATTATTATTTAAAGGCAGATCCAGCAGAAAAAGCATTGTTTGCTGAATTAGTAGAGCAGGAAGATCCTGATTTAC
TTGACTGGTTTATGGAAGTATCTGAACCGCCGCGTACAGAATTACGTGATTTTATTCATAAATTAAAGCATTATGTTCAT
GGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3KUX0