Detailed information of TA system TA144025

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1005361..1005859
• Replicon: chromosome
• Accession: NZ_CP046335
• Organism: Streptococcus mitis strain FDAARGOS_684

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F9HDX7
• Locus tag: FOB92_RS04980
• Protein ID: WP_004239453.1
• Coordinates: 1005361..1005615 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F9HDX8
• Locus tag: FOB92_RS04985
• Protein ID: WP_000208079.1
• Coordinates: 1005617..1005859 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB92_RS04960	1000371..1002272	-	1902	WP_000584858.1	ABC-F family ATP-binding cassette domain-containing protein	-
FOB92_RS04965	1002426..1004144	+	1719	WP_000121686.1	phospho-sugar mutase	-
FOB92_RS04970	1004256..1004603	+	348	WP_000434630.1	thiol reductase thioredoxin	-
FOB92_RS04975	1004641..1005318	-	678	WP_000566125.1	ion transporter	-
FOB92_RS04980	1005361..1005615	-	255	WP_004239453.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FOB92_RS04985	1005617..1005859	-	243	WP_000208079.1	hypothetical protein	Antitoxin
FOB92_RS04990	1005950..1006759	-	810	WP_000004960.1	MBL fold metallo-hydrolase	-
FOB92_RS04995	1006752..1008110	-	1359	WP_000571163.1	cell wall metabolism sensor histidine kinase VicK	-
FOB92_RS05000	1008103..1008810	-	708	WP_000722072.1	response regulator transcription factor	-
FOB92_RS05005	1008866..1010041	-	1176	WP_000886130.1	A/G-specific adenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10112.82 Da
• Isoelectric Point: 10.7632

>T144025 WP_004239453.1 NZ_CP046335:c1005615-1005361 [Streptococcus mitis]
MYKLVPTRRFIKQLKKLDRYTQKIITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVIATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T144025 NZ_CP061637:41445-41804 [Acinetobacter seifertii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9206.40 Da
• Isoelectric Point: 3.9338

>AT144025 WP_000208079.1 NZ_CP046335:c1005859-1005617 [Streptococcus mitis]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLEDE

Nucleotide

• Length: 243 bp

>AT144025 NZ_CP061637:41804-42103 [Acinetobacter seifertii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Structures

Toxin

• AlphaFold DB: F9HDX7

Antitoxin

• AlphaFold DB: F9HDX8