144023

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 472653..473280 Replicon chromosome
Accession NZ_CP046335
Organism Streptococcus mitis strain FDAARGOS_684

Toxin (Protein)


Gene name parE Uniprot ID I0SM96
Locus tag FOB92_RS02515 Protein ID WP_000384864.1
Coordinates 472930..473280 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1X1KIL2
Locus tag FOB92_RS02510 Protein ID WP_000951984.1
Coordinates 472653..472940 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB92_RS02485 468436..469275 + 840 WP_001192117.1 carbohydrate ABC transporter permease -
FOB92_RS02490 469448..469900 + 453 WP_000575452.1 YhcH/YjgK/YiaL family protein -
FOB92_RS02495 469920..470564 + 645 WP_000057476.1 DUF624 domain-containing protein -
FOB92_RS02500 470737..471654 + 918 WP_001281493.1 dihydrodipicolinate synthase family protein -
FOB92_RS02505 471672..472556 + 885 WP_000150262.1 ROK family protein -
FOB92_RS02510 472653..472940 + 288 WP_000951984.1 hypothetical protein Antitoxin
FOB92_RS02515 472930..473280 + 351 WP_000384864.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOB92_RS02520 473342..474193 - 852 WP_000360341.1 MurR/RpiR family transcriptional regulator -
FOB92_RS02525 474385..476442 + 2058 WP_004238750.1 penicillin-binding protein PBP2B -
FOB92_RS02530 476453..477049 + 597 WP_000966754.1 recombination mediator RecR -
FOB92_RS02535 477224..478267 + 1044 WP_000814640.1 D-alanine--D-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13718.86 Da        Isoelectric Point: 9.8158

>T144023 WP_000384864.1 NZ_CP046335:472930-473280 [Streptococcus mitis]
MDYKKYRILYSPRVIDSLDKIYQYIAEEIGSVEAARRKVASIRKDINRLEIFPQAGFDADEKFGKKLDPRYQTRGLTLSK
DYIVLYTIVEDTVRLAYLLPSKSDYMKLFKTKSRYD

Download         Length: 351 bp

>T144023 NZ_CP061634:c3613038-3612649 [Acinetobacter seifertii]
TTGATCAACCAATTGAATTTTAAACTGAAATATAGCCGTTTCGCGATTGTATTTCAGTTTTTTATTGGCCTATGTTTAGC
AGCTCTGTTTTATCAGCTGATACCAATACTCTGGTGGTTGGTTACGCTCTGTTTATTATTTATAAGTTTTATTTTCTTTT
TAAAGCGACCACAGCTCGTTCAAATTGCCTATTTAGATCAGAAATTATGGTCTCTTAGCTTTCATTCAGAACAAACCATT
TCTCGTGTAGAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGGTCTATTTTAAGGGTGATAAAACATTAACTTC
TGTTATTTGGTTTGATCAAATGTCCTTATCTCAATGGAAACAGCTTAAGACTTTAGAAAAATTCTATTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10829.20 Da        Isoelectric Point: 4.1285

>AT144023 WP_000951984.1 NZ_CP046335:472653-472940 [Streptococcus mitis]
MAIANSNKIVTFQANRELVNDAMEVLKEQNLSLSSALRLFLKNVAVTNEVDLLSEEELEKEYLFRQLQAEVQESYAKIEA
GNYLTDEDVVTRYGL

Download         Length: 288 bp

>AT144023 NZ_CP061634:c3613290-3613045 [Acinetobacter seifertii]
ATGACCTTGGAAGAACGTAAAGTAGTTTATCGCGCACGCCGCGGTTTAAAGGAAATTGATGTCTATTTTGACCCGTATGT
GAAAAATTATTATTTAAAGGCAGATCCAGCAGAAAAAGCATTGTTTGCTGAATTAGTAGAGCAGGAAGATCCTGATTTAC
TTGACTGGTTTATGGAAGTATCTGAACCGCCGCGTACAGAATTACGTGATTTTATTCATAAATTAAAGCATTATGTTCAT
GGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I0SM96

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1KIL2

References