Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VapB |
Location | 158110..158675 | Replicon | plasmid unnamed2 |
Accession | NZ_CP046332 | ||
Organism | Cupriavidus metallidurans strain FDAARGOS_675 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | Q58AR3 |
Locus tag | FOB83_RS19875 | Protein ID | WP_011229306.1 |
Coordinates | 158110..158481 (-) | Length | 124 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | Q58AR4 |
Locus tag | FOB83_RS19880 | Protein ID | WP_011229305.1 |
Coordinates | 158478..158675 (-) | Length | 66 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FOB83_RS19840 | 154003..154452 | - | 450 | WP_011514800.1 | hypothetical protein | - |
FOB83_RS19845 | 154694..155233 | + | 540 | Protein_153 | SAM-dependent methyltransferase | - |
FOB83_RS19850 | 155310..155498 | + | 189 | WP_152564866.1 | hypothetical protein | - |
FOB83_RS19855 | 155495..155773 | + | 279 | WP_011514799.1 | hypothetical protein | - |
FOB83_RS19860 | 155835..156131 | + | 297 | WP_049799860.1 | hypothetical protein | - |
FOB83_RS19865 | 156505..156816 | + | 312 | WP_049799859.1 | hypothetical protein | - |
FOB83_RS19870 | 157502..157720 | - | 219 | Protein_158 | hypothetical protein | - |
FOB83_RS19875 | 158110..158481 | - | 372 | WP_011229306.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
FOB83_RS19880 | 158478..158675 | - | 198 | WP_011229305.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
FOB83_RS19885 | 158841..159566 | + | 726 | WP_011514795.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | - |
FOB83_RS19890 | 159563..160513 | + | 951 | WP_011229304.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
FOB83_RS19895 | 160547..160816 | + | 270 | WP_124682103.1 | hypothetical protein | - |
FOB83_RS19900 | 161105..161413 | + | 309 | WP_017514069.1 | hypothetical protein | - |
FOB83_RS19905 | 161852..162298 | + | 447 | WP_011514792.1 | hypothetical protein | - |
FOB83_RS19910 | 162330..162659 | - | 330 | WP_035882430.1 | hypothetical protein | - |
FOB83_RS19915 | 162735..162959 | - | 225 | WP_011514790.1 | hypothetical protein | - |
FOB83_RS19920 | 162956..163198 | - | 243 | WP_035882428.1 | hypothetical protein | - |
FOB83_RS19925 | 163211..163432 | - | 222 | WP_011229302.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..255356 | 255356 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 124 a.a. Molecular weight: 13613.83 Da Isoelectric Point: 5.6319
>T144021 WP_011229306.1 NZ_CP046332:c158481-158110 [Cupriavidus metallidurans]
MILVDTSVWIDHLNASDPMLISLLTQERVLIHPYVIGEISLGSLRDRDVVLGALRDLPRAPVATPEETLYLIEREGLFNR
GIGYGDTSLLASARLQPGIAIWTRDKRLKKVADELCLGAVLSH
MILVDTSVWIDHLNASDPMLISLLTQERVLIHPYVIGEISLGSLRDRDVVLGALRDLPRAPVATPEETLYLIEREGLFNR
GIGYGDTSLLASARLQPGIAIWTRDKRLKKVADELCLGAVLSH
Download Length: 372 bp
>T144021 NZ_CP061631:c64991-64635 [Acinetobacter seifertii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGACCTACGTGTTCAGCATCGAGGTAAATCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGTGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGACCTACGTGTTCAGCATCGAGGTAAATCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGTGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA
Antitoxin
Download Length: 66 a.a. Molecular weight: 7132.21 Da Isoelectric Point: 10.3509
>AT144021 WP_011229305.1 NZ_CP046332:c158675-158478 [Cupriavidus metallidurans]
MRTTIALDDELLAKAQAYTGLEEKTALVREALKALIQREAAKRLANLGGSQPGIEGVPRRRQDTK
MRTTIALDDELLAKAQAYTGLEEKTALVREALKALIQREAAKRLANLGGSQPGIEGVPRRRQDTK
Download Length: 198 bp
>AT144021 NZ_CP061631:c64642-64340 [Acinetobacter seifertii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A482J4V6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A482J603 |