Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 158110..158675 Replicon plasmid unnamed2
Accession NZ_CP046332
Organism Cupriavidus metallidurans strain FDAARGOS_675

Toxin (Protein)


Gene name vapC Uniprot ID Q58AR3
Locus tag FOB83_RS19875 Protein ID WP_011229306.1
Coordinates 158110..158481 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q58AR4
Locus tag FOB83_RS19880 Protein ID WP_011229305.1
Coordinates 158478..158675 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB83_RS19840 154003..154452 - 450 WP_011514800.1 hypothetical protein -
FOB83_RS19845 154694..155233 + 540 Protein_153 SAM-dependent methyltransferase -
FOB83_RS19850 155310..155498 + 189 WP_152564866.1 hypothetical protein -
FOB83_RS19855 155495..155773 + 279 WP_011514799.1 hypothetical protein -
FOB83_RS19860 155835..156131 + 297 WP_049799860.1 hypothetical protein -
FOB83_RS19865 156505..156816 + 312 WP_049799859.1 hypothetical protein -
FOB83_RS19870 157502..157720 - 219 Protein_158 hypothetical protein -
FOB83_RS19875 158110..158481 - 372 WP_011229306.1 type II toxin-antitoxin system VapC family toxin Toxin
FOB83_RS19880 158478..158675 - 198 WP_011229305.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FOB83_RS19885 158841..159566 + 726 WP_011514795.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
FOB83_RS19890 159563..160513 + 951 WP_011229304.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
FOB83_RS19895 160547..160816 + 270 WP_124682103.1 hypothetical protein -
FOB83_RS19900 161105..161413 + 309 WP_017514069.1 hypothetical protein -
FOB83_RS19905 161852..162298 + 447 WP_011514792.1 hypothetical protein -
FOB83_RS19910 162330..162659 - 330 WP_035882430.1 hypothetical protein -
FOB83_RS19915 162735..162959 - 225 WP_011514790.1 hypothetical protein -
FOB83_RS19920 162956..163198 - 243 WP_035882428.1 hypothetical protein -
FOB83_RS19925 163211..163432 - 222 WP_011229302.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..255356 255356


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-44)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13613.83 Da        Isoelectric Point: 5.6319

>T144021 WP_011229306.1 NZ_CP046332:c158481-158110 [Cupriavidus metallidurans]
MILVDTSVWIDHLNASDPMLISLLTQERVLIHPYVIGEISLGSLRDRDVVLGALRDLPRAPVATPEETLYLIEREGLFNR
GIGYGDTSLLASARLQPGIAIWTRDKRLKKVADELCLGAVLSH

Download         Length: 372 bp

>T144021 NZ_CP061631:c64991-64635 [Acinetobacter seifertii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGACCTACGTGTTCAGCATCGAGGTAAATCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGTGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7132.21 Da        Isoelectric Point: 10.3509

>AT144021 WP_011229305.1 NZ_CP046332:c158675-158478 [Cupriavidus metallidurans]
MRTTIALDDELLAKAQAYTGLEEKTALVREALKALIQREAAKRLANLGGSQPGIEGVPRRRQDTK

Download         Length: 198 bp

>AT144021 NZ_CP061631:c64642-64340 [Acinetobacter seifertii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A482J4V6

Antitoxin

Source ID Structure
AlphaFold DB A0A482J603

References