Detailed information of TA system TA144014

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParE-CopA/ParE-RHH
• Location: 1234483..1235048
• Replicon: chromosome
• Accession: NZ_CP046329
• Organism: Shewanella putrefaciens strain FDAARGOS_681

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FOB89_RS05630
• Protein ID: WP_011920069.1
• Coordinates: 1234755..1235048 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: copA
• Uniprot ID: V1D9S8
• Locus tag: FOB89_RS05625
• Protein ID: WP_011920070.1
• Coordinates: 1234483..1234767 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB89_RS05590	1230274..1230471	-	198	WP_011920077.1	AlpA family transcriptional regulator	-
FOB89_RS05595	1230646..1231110	+	465	WP_086023742.1	DNA repair protein RadC	-
FOB89_RS05600	1231151..1231513	+	363	WP_011920075.1	hypothetical protein	-
FOB89_RS05605	1231653..1232027	+	375	WP_011920074.1	type IV toxin-antitoxin system YeeU family antitoxin	-
FOB89_RS05610	1232232..1232645	+	414	WP_011920073.1	DUF2787 domain-containing protein	-
FOB89_RS05615	1232768..1233328	+	561	WP_006086652.1	tyrosine-type recombinase/integrase	-
FOB89_RS05620	1233474..1234196	+	723	WP_011920071.1	lecithin retinol acyltransferase family protein	-
FOB89_RS05625	1234483..1234767	+	285	WP_011920070.1	CopG family ribbon-helix-helix protein	Antitoxin
FOB89_RS05630	1234755..1235048	+	294	WP_011920069.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FOB89_RS05635	1235235..1235903	-	669	WP_011920068.1	inovirus Gp2 family protein	-
FOB89_RS05640	1236217..1237653	-	1437	WP_151206322.1	hypothetical protein	-
FOB89_RS05645	1237821..1239785	+	1965	WP_049766860.1	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (7-44)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11139.68 Da
• Isoelectric Point: 5.8404

>T144014 WP_011920069.1 NZ_CP046329:1234755-1235048 [Shewanella putrefaciens]
MPQIIFTATALRDLERLREFLRSKNPPAAQRAASAIINTIRKLESYPDIGRPIDDNDFSFRELLIDFGDTGYLAMYQYDG
GERLTVLCIRHQKEAGY

Nucleotide

• Length: 294 bp

>T144014 NZ_CP061622:58269-58625 [Acinetobacter seifertii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGACCTACGTGTTCAGCATCGAGGTAAATCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGTGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10955.29 Da
• Isoelectric Point: 6.3342

>AT144014 WP_011920070.1 NZ_CP046329:1234483-1234767 [Shewanella putrefaciens]
MSTIKPVSVKLDADIKARVEHLAETRKRSSHWMMREAIREYVEREEKREALQQEALRAWEEHQTSGLHVTGDEVVSWLES
WGSENEKAAPTCHK

Nucleotide

• Length: 285 bp

>AT144014 NZ_CP061622:58618-58920 [Acinetobacter seifertii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA

Structures

Antitoxin

• AlphaFold DB: V1D9S8