Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 452419..452990 Replicon chromosome
Accession NZ_CP046329
Organism Shewanella putrefaciens strain FDAARGOS_681

Toxin (Protein)


Gene name parE Uniprot ID A0A2I8S8S5
Locus tag FOB89_RS02115 Protein ID WP_011918375.1
Coordinates 452419..452730 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Z3MW28
Locus tag FOB89_RS02120 Protein ID WP_011787805.1
Coordinates 452730..452990 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB89_RS02100 447960..448367 + 408 WP_004364961.1 Cd(II)/Pb(II)-responsive transcriptional regulator -
FOB89_RS02105 448585..449262 - 678 Protein_406 integrase -
FOB89_RS02110 449315..452395 - 3081 WP_011787830.1 Tn3 family transposase -
FOB89_RS02115 452419..452730 - 312 WP_011918375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOB89_RS02120 452730..452990 - 261 WP_011787805.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FOB89_RS02125 453160..453780 + 621 WP_011787804.1 recombinase family protein -
FOB89_RS02130 453898..454230 - 333 WP_011787803.1 TraR/DksA C4-type zinc finger protein -
FOB89_RS02135 454321..455175 - 855 WP_011787802.1 universal stress protein -
FOB89_RS02140 455210..456664 - 1455 WP_156005080.1 SulP family inorganic anion transporter -
FOB89_RS02145 457197..457334 - 138 Protein_414 CopG family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 443756..472751 28995


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-61)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11862.70 Da        Isoelectric Point: 8.5341

>T144013 WP_011918375.1 NZ_CP046329:c452730-452419 [Shewanella putrefaciens]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T144013 NZ_CP061620:c3689682-3689293 [Acinetobacter seifertii]
TTGATCAACCAATTGAATTTTAAACTGAAATATAGCCGTTTCGCGATTGTATTTCAGTTTTTTATTGGCCTATGTTTAGC
AGCTCTGTTTTATCAGCTGATACCAATACTCTGGTGGTTGGTTACGCTCTGTTTATTATTTATAAGTTTTATTTTCTTTT
TAAAGCGACCACAGCTCGTTCAAATTGCCTATTTAGATCAGAAATTATGGTCTCTTAGCTTTCATTCAGAACAAACCATT
TCTCGTGTAGAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGGTCTATTTTAAGGGTGATAAAACATTAACTTC
TGTTATTTGGTTTGATCAAATGTCCTTATCTCAATGGAAACAGCTTAAGACTTTAGAAAAATTCTATTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9312.71 Da        Isoelectric Point: 6.4546

>AT144013 WP_011787805.1 NZ_CP046329:c452990-452730 [Shewanella putrefaciens]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAITDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT144013 NZ_CP061620:c3689934-3689689 [Acinetobacter seifertii]
ATGACCTTGGAAGAACGTAAAGTAGTTTATCGCGCACGCCGCGGTTTAAAGGAAATTGATGTCTATTTTGACCCGTATGT
GAAAAATTATTATTTAAAGGCAGATCCAGCAGAAAAAGCATTGTTTGCTGAATTAGTAGAGCAGGAAGATCCTGATTTAC
TTGACTGGTTTATGGAAGTATCTGAACCGCCGCGTACAGAATTACGTGATTTTATTCATAAATTAAAGCATTATGTTCAT
GGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S8S5

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MW28

References