Detailed information of TA system TA144012

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 201555..202105
• Replicon: chromosome
• Accession: NZ_CP046329
• Organism: Shewanella putrefaciens strain FDAARGOS_681

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FOB89_RS00925
• Protein ID: WP_011918510.1
• Coordinates: 201806..202105 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: FOB89_RS00920
• Protein ID: WP_011918511.1
• Coordinates: 201555..201797 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB89_RS00895	196665..197864	+	1200	WP_041420515.1	beta-ketoacyl-[acyl-carrier-protein] synthase family protein	-
FOB89_RS00900	197869..198402	+	534	WP_011918515.1	hotdog family protein	-
FOB89_RS00905	198515..199240	+	726	WP_011918514.1	3-ketoacyl-ACP reductase FabG2	-
FOB89_RS00910	199241..200500	+	1260	WP_011918513.1	beta-ketoacyl-ACP synthase	-
FOB89_RS00915	200532..201275	+	744	WP_011918512.1	hypothetical protein	-
FOB89_RS00920	201555..201797	+	243	WP_011918511.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FOB89_RS00925	201806..202105	+	300	WP_011918510.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FOB89_RS00930	202635..203348	-	714	WP_014609649.1	hypothetical protein	-
FOB89_RS00935	203708..204184	+	477	WP_011918508.1	GNAT family N-acetyltransferase	-
FOB89_RS00940	204235..205422	-	1188	WP_011918507.1	benzoate/H(+) symporter BenE family transporter	-
FOB89_RS00945	205586..206152	+	567	WP_011918506.1	XRE family transcriptional regulator	-
FOB89_RS00950	206289..206885	-	597	WP_011787674.1	FMN-dependent NADH-azoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-64)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11598.24 Da
• Isoelectric Point: 8.8270

>T144012 WP_011918510.1 NZ_CP046329:201806-202105 [Shewanella putrefaciens]
MNNKRYKLSRLSQTHLQQIKDYTLQHFSESQWHKYKESLISGLQMLADNPGLGRSCEDIYPNGFYFPIAKHTAYFTKEDD
FILIVALLGQPQLPQNHLK

Nucleotide

• Length: 300 bp

>T144012 NZ_CP061616:c35990-35715 [Acinetobacter seifertii]
ATGTTAATCGTTGAGTGGACACCCAACGCTATTGAGGATTTAGAAGCAATTTCAGACTATATAGCTGAACACAATCCTAT
TGCTGCATACAACTTGGAAGATCACATTCTAAAATGCGCTGAAAGCCTATCAGAACATCCATATAAGGGTGTTTCTGGAC
GTGTAGTGGGTACAAGGGAAATGCTGGTACACCCGAACTACTGGCTGATTTATGAAGTCTCAGACATGATCAAAATCAAA
GGCGTACTTCATACTAGAAAATCATATCCGGATTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8936.14 Da
• Isoelectric Point: 5.0758

>AT144012 WP_011918511.1 NZ_CP046329:201555-201797 [Shewanella putrefaciens]
VQTLTANEAKRNFGELLLNAQREPIKISKNSKDAVVVMSIHDYEQLEAMKADYLKHCFNAAKEDLAKGNVVDGEDFLNAL

Nucleotide

• Length: 243 bp

>AT144012 NZ_CP061616:c36165-35977 [Acinetobacter seifertii]
ATGAATACCGTTTTCGATCCTATAGTGTCTGAGTTTGACAGCTCTGATCATGAATCTGAATATAATGCATGGTTCAAAGC
GAAAATTGAAAAATCAATGGCTGATACACGTCCAACTGTACCACACGACCAGGTAGTAGCACGTTTAAAAAAACGTCGTG
AGGAAAGAACAACTAATGTTAATCGTTGA