Detailed information of TA system TA144007

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3907023..3907677
• Replicon: chromosome
• Accession: NZ_CP046320
• Organism: Gordonia bronchialis strain FDAARGOS_676

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FOB84_RS18125
• Protein ID: WP_052298363.1
• Coordinates: 3907258..3907677 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FOB84_RS18120
• Protein ID: WP_083775533.1
• Coordinates: 3907023..3907268 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB84_RS18090	3903465..3904307	-	843	Protein_3580	GTPase	-
FOB84_RS18095	3904316..3904609	+	294	WP_012833032.1	hypothetical protein	-
FOB84_RS18100	3904646..3904999	+	354	WP_012833031.1	hypothetical protein	-
FOB84_RS18105	3905160..3905534	+	375	WP_012833030.1	VOC family protein	-
FOB84_RS18110	3905696..3905983	+	288	WP_012833029.1	hypothetical protein	-
FOB84_RS18115	3906108..3906988	+	881	Protein_3585	putative DNA binding domain-containing protein	-
FOB84_RS18120	3907023..3907268	+	246	WP_083775533.1	hypothetical protein	Antitoxin
FOB84_RS18125	3907258..3907677	+	420	WP_052298363.1	PIN domain-containing protein	Toxin
FOB84_RS18130	3907688..3908788	-	1101	WP_012833026.1	epoxide hydrolase	-
FOB84_RS18135	3908886..3909320	+	435	WP_012833025.1	MarR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15188.41 Da
• Isoelectric Point: 6.2135

>T144007 WP_052298363.1 NZ_CP046320:3907258-3907677 [Gordonia bronchialis]
MLLDINVLVALSWDQHVHHGVAHERFAQLTEWSTCPVTEAGLVRVLMTESAVGRVVTGAEALGQLAALRTVTGWGFLHDD
ASLADSVIDLRVLMGRRQVTDLHLVNLAARNGRKLATFDAGLRESLVPADRAWVEVWSA

Nucleotide

• Length: 420 bp

>T144007 NZ_CP061603:482773-483162 [Acinetobacter seifertii]
TTGATCAACCAATTGAATTTTAAACTGAAATATAGCCGTTTCGCGATTGTATTTCAGTTTTTTATTGGCCTATGTTTAGC
AGCTCTGTTTTATCAGCTGATACCAATACTCTGGTGGTTGGTTACGCTCTGTTTATTATTTATAAGTTTTATTTTCTTTT
TAAAGCGACCACAGCTCGTTCAAATTGCCTATTTAGATCAGAAATTATGGTCTCTTAGCTTTCATTCAGAACAAACCATT
TCTCGTGTAGAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGGTCTATTTTAAGGGTGATAAAACATTAACTTC
TGTTATTTGGTTTGATCAAATGTCCTTATCTCAATGGAAACAGCTTAAGACTTTAGAAAAATTCTATTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8087.99 Da
• Isoelectric Point: 4.6140

>AT144007 WP_083775533.1 NZ_CP046320:3907023-3907268 [Gordonia bronchialis]
VRTTLDLDPVVLSAARAKAKADGISLGKAVSELARAGLSAPRSAAATSAPSGFPVLTGVPGHPVTDDAVAEYRDDDVTDA
S

Nucleotide

• Length: 246 bp

>AT144007 NZ_CP061603:482521-482766 [Acinetobacter seifertii]
ATGACCTTGGAAGAACGTAAAGTAGTTTATCGCGCACGCCGCGGTTTAAAGGAAATTGATGTCTATTTTGACCCGTATGT
GAAAAATTATTATTTAAAGGCAGATCCAGCAGAAAAAGCATTGTTTGCTGAATTAGTAGAGCAGGAAGATCCTGATTTAC
TTGACTGGTTTATGGAAGTATCTGAACCGCCGCGTACAGAATTACGTGATTTTATTCATAAATTAAAGCATTATGTTCAT
GGCTGA