144006

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 2272763..2273325 Replicon chromosome
Accession NZ_CP046320
Organism Gordonia bronchialis strain FDAARGOS_676

Toxin (Protein)


Gene name relE Uniprot ID D0LF01
Locus tag FOB84_RS10575 Protein ID WP_012834418.1
Coordinates 2273035..2273325 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D0L7Y1
Locus tag FOB84_RS10570 Protein ID WP_012834419.1
Coordinates 2272763..2273038 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB84_RS10545 2267934..2268155 + 222 WP_005179582.1 hypothetical protein -
FOB84_RS10550 2268768..2269145 - 378 WP_005179587.1 metalloregulator ArsR/SmtB family transcription factor -
FOB84_RS10555 2269270..2270706 + 1437 WP_012834420.1 mercury(II) reductase -
FOB84_RS10560 2270731..2271282 + 552 WP_005179589.1 MerR family transcriptional regulator -
FOB84_RS10565 2271224..2271865 + 642 WP_005179592.1 organomercurial lyase MerB -
FOB84_RS10570 2272763..2273038 + 276 WP_012834419.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FOB84_RS10575 2273035..2273325 + 291 WP_012834418.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOB84_RS10580 2273367..2273645 + 279 WP_012834417.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(14-94)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10746.28 Da        Isoelectric Point: 11.1310

>T144006 WP_012834418.1 NZ_CP046320:2273035-2273325 [Gordonia bronchialis]
MSDAPTDSPAPYRVEVASPARRDLQRLPSRIVHAVIEFISGPLAGNPHRLSKPLRDDLGGLHSARRGDYRILLRIDAPNH
TIVVVRIDHRAHAYRT

Download         Length: 291 bp

>T144006 NZ_CP061596:458512-458901 [Acinetobacter seifertii]
TTGGTCAACCAATTGAATTTTAAACTGAAATATAGCCGTTTCTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTGTTTTATCAACTCCTACCAATACTCTGGTGGTTGGTTACGGTCAGTTTACTATTTATAAGTTTTGTTTTCTTTT
TAAAGCGACCACAGCTCGCTCAAATTGCTTATTTAGATCAGAAATTATGGTCACTTAGCTTTCATTCAGAACAAACCATT
TCTCGTGTAGAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGGCATAAAACATTAACTTC
TGTGATTTGGTTTGATCAAATGTCCTTATCTCAATGGAAACAGCTTAAGACTTTAGAAAAATTCTATTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9726.88 Da        Isoelectric Point: 4.6221

>AT144006 WP_012834419.1 NZ_CP046320:2272763-2273038 [Gordonia bronchialis]
MTTVPLGEAKDKLSALIDSAETTHDIITITKHGKPAAVLMSADDLESLHETIYWLSRAGVRDDVATADAEYAAGHTASID
DLRAEHGMPPK

Download         Length: 276 bp

>AT144006 NZ_CP061596:458260-458505 [Acinetobacter seifertii]
ATGACCTTGGAAGAACGTAAAGTAGTTTATCGCGCACGCCGCGGTTTAAAGGAAATTGATGTCTATTTTGACCCGTATGT
GAAAAATTATTATTTAAAGGCAGATCCAGCAGAAAAAGCATTATTTGCTGAATTAGTAGAGCAGGAAGATCCTGACTTAC
TTGACTGGTTTATGGAAGTATCTGAACCGCCGCGTACAGAATTACGTGATTTTATTCATAAATTAAAGCATTATGTGCAT
GGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D0LF01

Antitoxin

Source ID Structure
AlphaFold DB D0L7Y1

References