Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 209321..209836 Replicon chromosome
Accession NZ_CP046319
Organism Micrococcus luteus strain FDAARGOS_677

Toxin (Protein)


Gene name relE Uniprot ID A0A4Y1LR91
Locus tag FOB85_RS01045 Protein ID WP_041103932.1
Coordinates 209582..209836 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A229HG25
Locus tag FOB85_RS01040 Protein ID WP_036340860.1
Coordinates 209321..209581 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB85_RS01020 204416..205504 - 1089 WP_196773884.1 catalase family protein -
FOB85_RS01025 205715..206002 + 288 Protein_199 ABC-F family ATP-binding cassette domain-containing protein -
FOB85_RS01030 206548..207702 - 1155 WP_155932744.1 glycerate kinase -
FOB85_RS01035 207732..209135 - 1404 WP_155932746.1 GntP family permease -
FOB85_RS01040 209321..209581 + 261 WP_036340860.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FOB85_RS01045 209582..209836 + 255 WP_041103932.1 Txe/YoeB family addiction module toxin Toxin
FOB85_RS01050 209838..210404 + 567 WP_041103934.1 mismatch-specific DNA-glycosylase -
FOB85_RS01055 210448..211230 - 783 WP_069941698.1 SCO1664 family protein -
FOB85_RS01060 211230..211772 - 543 WP_155932748.1 DUF3090 domain-containing protein -
FOB85_RS01065 211769..212494 - 726 WP_169577815.1 MSMEG_4193 family putative phosphomutase -
FOB85_RS01070 212792..212977 + 186 Protein_208 hypothetical protein -
FOB85_RS01075 213092..213388 + 297 Protein_209 hypothetical protein -
FOB85_RS01080 213597..214243 + 647 Protein_210 aquaporin Z -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9996.33 Da        Isoelectric Point: 7.3149

>T144005 WP_041103932.1 NZ_CP046319:209582-209836 [Micrococcus luteus]
VRLVWDRSAWEDYTHWQTTDRKVLKRINTLIDAALRDPFDGIGKPEQLKYGAPGAWSRRITEEHRLVYLVDGEDLIILQA
RYHY

Download         Length: 255 bp

>T144005 NZ_CP061592:c3708451-3708062 [Acinetobacter seifertii]
TTGATCAACCAATTGAATTTTAAACTGAAATATAGCCGTTTCGCGATTGTATTTCAGTTTTTTATTGGCCTATGTTTAGC
AGCTCTGTTTTATCAGCTGATACCAATACTCTGGTGGTTGGTTACGCTCTGTTTATTATTTATAAGTTTTATTTTCTTTT
TAAAGCGACCACAGCTCGTTCAAATTGCCTATTTAGATCAGAAATTATGGTCTCTTAGCTTTCATTCAGAACAAACCATT
TCTCGTGTAGAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGGTCTATTTTAAGGGTGATAAAACATTAACTTC
TGTTATTTGGTTTGATCAAATGTCCTTATCTCAATGGAAACAGCTTAAGACTTTAGAAAAATTCTATTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9597.74 Da        Isoelectric Point: 4.8359

>AT144005 WP_036340860.1 NZ_CP046319:209321-209581 [Micrococcus luteus]
MSISASEARKTLFPLIERVNADRDAVEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYERARAGSVEEHALD
RMDGDA

Download         Length: 261 bp

>AT144005 NZ_CP061592:c3708703-3708458 [Acinetobacter seifertii]
ATGACCTTGGAAGAACGTAAAGTAGTTTATCGCGCACGCCGCGGTTTAAAGGAAATTGATGTCTATTTTGACCCGTATGT
GAAAAATTATTATTTAAAGGCAGATCCAGCAGAAAAAGCATTGTTTGCTGAATTAGTAGAGCAGGAAGATCCTGATTTAC
TTGACTGGTTTATGGAAGTATCTGAACCGCCGCGTACAGAATTACGTGATTTTATTCATAAATTAAAGCATTATGTTCAT
GGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y1LR91

Antitoxin

Source ID Structure
AlphaFold DB A0A229HG25

References