Detailed information of TA system TA144002

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1803002..1803569
• Replicon: chromosome
• Accession: NZ_CP046315
• Organism: Schaalia odontolytica strain FDAARGOS_732

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FOC40_RS07880
• Protein ID: WP_050755236.1
• Coordinates: 1803002..1803298 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4TXH9
• Locus tag: FOC40_RS07885
• Protein ID: WP_003794908.1
• Coordinates: 1803291..1803569 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC40_RS07860	1798290..1801040	+	2751	WP_003794916.1	DUF3516 domain-containing protein	-
FOC40_RS07865	1801045..1801485	-	441	WP_003794914.1	VOC family protein	-
FOC40_RS07870	1801545..1802108	-	564	WP_003793036.1	NAD(P)H-dependent oxidoreductase	-
FOC40_RS07875	1802253..1802969	-	717	WP_003794912.1	Pr6Pr family membrane protein	-
FOC40_RS07880	1803002..1803298	-	297	WP_050755236.1	type II toxin-antitoxin system YafQ family toxin	Toxin
FOC40_RS07885	1803291..1803569	-	279	WP_003794908.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FOC40_RS07890	1803628..1804386	-	759	WP_003794906.1	ABC transporter ATP-binding protein	-
FOC40_RS07895	1804379..1805275	-	897	WP_003794904.1	ABC transporter ATP-binding protein	-
FOC40_RS07900	1805272..1806093	-	822	WP_003794902.1	ABC transporter permease	-
FOC40_RS07905	1806090..1807058	-	969	WP_003794900.1	ABC transporter permease	-
FOC40_RS07910	1807058..1808545	-	1488	WP_050755225.1	ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (11-98)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-68)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11286.11 Da
• Isoelectric Point: 7.2443

>T144002 WP_050755236.1 NZ_CP046315:c1803298-1803002 [Schaalia odontolytica]
MSEPQRGQRALVMTGQFKKDLKRVRKRGLSIKELEAVIDLILAGEVLPPQWRDHLLTGDYAGFRECHIRPDWLLIYLDEP
EICVVTAIRTGSHSDLFQ

Nucleotide

• Length: 297 bp

>T144002 NZ_CP061582:c3615251-3614862 [Acinetobacter seifertii]
TTGATCAACCAATTGAATTTTAAACTGAAATATAGCCGTTTCGCGATTGTATTTCAGTTTTTTATTGGCCTATGTTTAGC
AGCTCTGTTTTATCAGCTGATACCAATACTCTGGTGGTTGGTTACGCTCTGTTTATTATTTATAAGTTTTATTTTCTTTT
TAAAGCGACCACAGCTCGTTCAAATTGCCTATTTAGATCAGAAATTATGGTCTCTTAGCTTTCATTCAGAACAAACCATT
TCTCGTGTAGAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGGTCTATTTTAAGGGTGATAAAACATTAACTTC
TGTTATTTGGTTTGATCAAATGTCCTTATCTCAATGGAAACAGCTTAAGACTTTAGAAAAATTCTATTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10195.48 Da
• Isoelectric Point: 4.6158

>AT144002 WP_003794908.1 NZ_CP046315:c1803569-1803291 [Schaalia odontolytica]
MKTATLNMRVDPSVKEEAERVYAQFGMNLTDAVNVFLHKSIMEGGLPFDLRQPRFNADTELAMREARDIAAGRVAATRYA
SAAQAFADVDDE

Nucleotide

• Length: 279 bp

>AT144002 NZ_CP061582:c3615503-3615258 [Acinetobacter seifertii]
ATGACCTTGGAAGAACGTAAAGTAGTTTATCGCGCACGCCGCGGTTTAAAGGAAATTGATGTCTATTTTGACCCGTATGT
GAAAAATTATTATTTAAAGGCAGATCCAGCAGAAAAAGCATTGTTTGCTGAATTAGTAGAGCAGGAAGATCCTGATTTAC
TTGACTGGTTTATGGAAGTATCTGAACCGCCGCGTACAGAATTACGTGATTTTATTCATAAATTAAAGCATTATGTTCAT
GGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A857AA51