Detailed information of TA system TA144001

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 369434..369923
• Replicon: chromosome
• Accession: NZ_CP046315
• Organism: Schaalia odontolytica strain FDAARGOS_732

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: FOC40_RS01610
• Protein ID: WP_081445526.1
• Coordinates: 369434..369697 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: D4TZA6
• Locus tag: FOC40_RS01615
• Protein ID: WP_003796016.1
• Coordinates: 369681..369923 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC40_RS01590	364852..366171	-	1320	WP_003796026.1	NAD(+)/NADH kinase	-
FOC40_RS01595	366426..367703	+	1278	WP_003796024.1	serine--tRNA ligase	-
FOC40_RS01600	367700..368617	+	918	WP_003796022.1	HAD hydrolase family protein	-
FOC40_RS01605	368833..369432	+	600	WP_003796020.1	TetR/AcrR family transcriptional regulator	-
FOC40_RS01610	369434..369697	-	264	WP_081445526.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FOC40_RS01615	369681..369923	-	243	WP_003796016.1	TraY domain-containing protein	Antitoxin
FOC40_RS01620	370173..371777	+	1605	WP_003796013.1	ATPase	-
FOC40_RS01625	371859..372740	+	882	WP_003796011.1	hypothetical protein	-
FOC40_RS01630	372832..373680	+	849	WP_039929627.1	glycosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-86)

Antitoxin

• Relaxosome protein TraY (10-36)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10094.59 Da
• Isoelectric Point: 10.6597

>T144001 WP_081445526.1 NZ_CP046315:c369697-369434 [Schaalia odontolytica]
MAWRAELSPRAVKQLSKLDKPTARRIIDYLRETASGEDPRSRGKGLTGNLAGFWRYRVGNYRIIASIEDDELLILAIHID
HRSRIYR

Nucleotide

• Length: 264 bp

>T144001 NZ_CP061579:c10507-10151 [Acinetobacter seifertii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGACCTACGTGTTCAGCATCGAGGTAAATCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGTGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8739.92 Da
• Isoelectric Point: 4.8004

>AT144001 WP_003796016.1 NZ_CP046315:c369923-369681 [Schaalia odontolytica]
MSTARVARSVKLDPEIDARLTALAQRTGRTKSFYMNRAIESALEEIELAYSLQAELEDIRAGRVASVSLDEAVKSLGLEG

Nucleotide

• Length: 243 bp

>AT144001 NZ_CP061579:c10158-9856 [Acinetobacter seifertii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA

Structures

Antitoxin

• AlphaFold DB: A0A857A5K1