Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 5809..6344 Replicon chromosome
Accession NZ_CP046315
Organism Schaalia odontolytica strain FDAARGOS_732

Toxin (Protein)


Gene name relE Uniprot ID D4U282
Locus tag FOC40_RS00040 Protein ID WP_003797211.1
Coordinates 6081..6344 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID D4U281
Locus tag FOC40_RS00035 Protein ID WP_003797209.1
Coordinates 5809..6078 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC40_RS00010 1424..2449 + 1026 WP_003797199.1 DUF1266 domain-containing protein -
FOC40_RS00015 2477..2746 + 270 WP_003797201.1 hypothetical protein -
FOC40_RS00020 2997..4706 + 1710 WP_003797206.1 ATP-binding cassette domain-containing protein -
FOC40_RS00025 4660..4947 - 288 WP_003797207.1 hypothetical protein -
FOC40_RS00030 5022..5393 + 372 WP_081445553.1 YjdF family protein -
FOC40_RS00035 5809..6078 + 270 WP_003797209.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FOC40_RS00040 6081..6344 + 264 WP_003797211.1 Txe/YoeB family addiction module toxin Toxin
FOC40_RS00045 6453..8144 - 1692 WP_003797213.1 methyltransferase -
FOC40_RS00050 8223..9191 + 969 WP_003797214.1 DUF808 domain-containing protein -
FOC40_RS00055 9354..10037 + 684 WP_003791861.1 superoxide dismutase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10470.91 Da        Isoelectric Point: 8.4982

>T144000 WP_003797211.1 NZ_CP046315:6081-6344 [Schaalia odontolytica]
MLKVLWTPHAWNDCVWWQFEDRKTLTRINALIADIQRNGNEGIGKPEPLRYEYTGFWSRRIDGRNRLVYRISEDTVEIVA
CRFHYGQ

Download         Length: 264 bp

>T144000 NZ_CP061578:c3673354-3672965 [Acinetobacter seifertii]
TTGATCAACCAATTGAATTTTAAACTGAAATATAGCCGTTTCGCGATTGTATTTCAGTTTTTTATTGGCCTATGTTTAGC
AGCTCTGTTTTATCAGCTGATACCAATACTCTGGTGGTTGGTTACGCTCTGTTTATTATTTATAAGTTTTATTTTCTTTT
TAAAGCGACCACAGCTCGTTCAAATTGCCTATTTAGATCAGAAATTATGGTCTCTTAGCTTTCATTCAGAACAAACCATT
TCTCGTGTAGAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGGTCTATTTTAAGGGTGATAAAACATTAACTTC
TGTTATTTGGTTTGATCAAATGTCCTTATCTCAATGGAAACAGCTTAAGACTTTAGAAAAATTCTATTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10381.60 Da        Isoelectric Point: 4.2876

>AT144000 WP_003797209.1 NZ_CP046315:5809-6078 [Schaalia odontolytica]
MKIMTYTESRAHYAEVLDQVVNDREEIVITRQGHESVVIMALDEYESLMETVYLMQSPANARHLRESIAQLRHGNLEEHD
LIDIPDEEN

Download         Length: 270 bp

>AT144000 NZ_CP061578:c3673606-3673361 [Acinetobacter seifertii]
ATGACCTTGGAAGAACGTAAAGTAGTTTATCGCGCACGCCGCGGTTTAAAGGAAATTGATGTCTATTTTGACCCGTATGT
GAAAAATTATTATTTAAAGGCAGATCCAGCAGAAAAAGCATTGTTTGCTGAATTAGTAGAGCAGGAAGATCCTGATTTAC
TTGACTGGTTTATGGAAGTATCTGAACCGCCGCGTACAGAATTACGTGATTTTATTCATAAATTAAAGCATTATGTTCAT
GGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A857A4N5

Antitoxin

Source ID Structure
AlphaFold DB A0A857A4E1

References