Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relE-yefM/YoeB-RelB |
Location | 5809..6344 | Replicon | chromosome |
Accession | NZ_CP046315 | ||
Organism | Schaalia odontolytica strain FDAARGOS_732 |
Toxin (Protein)
Gene name | relE | Uniprot ID | D4U282 |
Locus tag | FOC40_RS00040 | Protein ID | WP_003797211.1 |
Coordinates | 6081..6344 (+) | Length | 88 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | D4U281 |
Locus tag | FOC40_RS00035 | Protein ID | WP_003797209.1 |
Coordinates | 5809..6078 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FOC40_RS00010 | 1424..2449 | + | 1026 | WP_003797199.1 | DUF1266 domain-containing protein | - |
FOC40_RS00015 | 2477..2746 | + | 270 | WP_003797201.1 | hypothetical protein | - |
FOC40_RS00020 | 2997..4706 | + | 1710 | WP_003797206.1 | ATP-binding cassette domain-containing protein | - |
FOC40_RS00025 | 4660..4947 | - | 288 | WP_003797207.1 | hypothetical protein | - |
FOC40_RS00030 | 5022..5393 | + | 372 | WP_081445553.1 | YjdF family protein | - |
FOC40_RS00035 | 5809..6078 | + | 270 | WP_003797209.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
FOC40_RS00040 | 6081..6344 | + | 264 | WP_003797211.1 | Txe/YoeB family addiction module toxin | Toxin |
FOC40_RS00045 | 6453..8144 | - | 1692 | WP_003797213.1 | methyltransferase | - |
FOC40_RS00050 | 8223..9191 | + | 969 | WP_003797214.1 | DUF808 domain-containing protein | - |
FOC40_RS00055 | 9354..10037 | + | 684 | WP_003791861.1 | superoxide dismutase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 88 a.a. Molecular weight: 10470.91 Da Isoelectric Point: 8.4982
>T144000 WP_003797211.1 NZ_CP046315:6081-6344 [Schaalia odontolytica]
MLKVLWTPHAWNDCVWWQFEDRKTLTRINALIADIQRNGNEGIGKPEPLRYEYTGFWSRRIDGRNRLVYRISEDTVEIVA
CRFHYGQ
MLKVLWTPHAWNDCVWWQFEDRKTLTRINALIADIQRNGNEGIGKPEPLRYEYTGFWSRRIDGRNRLVYRISEDTVEIVA
CRFHYGQ
Download Length: 264 bp
>T144000 NZ_CP061578:c3673354-3672965 [Acinetobacter seifertii]
TTGATCAACCAATTGAATTTTAAACTGAAATATAGCCGTTTCGCGATTGTATTTCAGTTTTTTATTGGCCTATGTTTAGC
AGCTCTGTTTTATCAGCTGATACCAATACTCTGGTGGTTGGTTACGCTCTGTTTATTATTTATAAGTTTTATTTTCTTTT
TAAAGCGACCACAGCTCGTTCAAATTGCCTATTTAGATCAGAAATTATGGTCTCTTAGCTTTCATTCAGAACAAACCATT
TCTCGTGTAGAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGGTCTATTTTAAGGGTGATAAAACATTAACTTC
TGTTATTTGGTTTGATCAAATGTCCTTATCTCAATGGAAACAGCTTAAGACTTTAGAAAAATTCTATTAA
TTGATCAACCAATTGAATTTTAAACTGAAATATAGCCGTTTCGCGATTGTATTTCAGTTTTTTATTGGCCTATGTTTAGC
AGCTCTGTTTTATCAGCTGATACCAATACTCTGGTGGTTGGTTACGCTCTGTTTATTATTTATAAGTTTTATTTTCTTTT
TAAAGCGACCACAGCTCGTTCAAATTGCCTATTTAGATCAGAAATTATGGTCTCTTAGCTTTCATTCAGAACAAACCATT
TCTCGTGTAGAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGGTCTATTTTAAGGGTGATAAAACATTAACTTC
TGTTATTTGGTTTGATCAAATGTCCTTATCTCAATGGAAACAGCTTAAGACTTTAGAAAAATTCTATTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10381.60 Da Isoelectric Point: 4.2876
>AT144000 WP_003797209.1 NZ_CP046315:5809-6078 [Schaalia odontolytica]
MKIMTYTESRAHYAEVLDQVVNDREEIVITRQGHESVVIMALDEYESLMETVYLMQSPANARHLRESIAQLRHGNLEEHD
LIDIPDEEN
MKIMTYTESRAHYAEVLDQVVNDREEIVITRQGHESVVIMALDEYESLMETVYLMQSPANARHLRESIAQLRHGNLEEHD
LIDIPDEEN
Download Length: 270 bp
>AT144000 NZ_CP061578:c3673606-3673361 [Acinetobacter seifertii]
ATGACCTTGGAAGAACGTAAAGTAGTTTATCGCGCACGCCGCGGTTTAAAGGAAATTGATGTCTATTTTGACCCGTATGT
GAAAAATTATTATTTAAAGGCAGATCCAGCAGAAAAAGCATTGTTTGCTGAATTAGTAGAGCAGGAAGATCCTGATTTAC
TTGACTGGTTTATGGAAGTATCTGAACCGCCGCGTACAGAATTACGTGATTTTATTCATAAATTAAAGCATTATGTTCAT
GGCTGA
ATGACCTTGGAAGAACGTAAAGTAGTTTATCGCGCACGCCGCGGTTTAAAGGAAATTGATGTCTATTTTGACCCGTATGT
GAAAAATTATTATTTAAAGGCAGATCCAGCAGAAAAAGCATTGTTTGCTGAATTAGTAGAGCAGGAAGATCCTGATTTAC
TTGACTGGTTTATGGAAGTATCTGAACCGCCGCGTACAGAATTACGTGATTTTATTCATAAATTAAAGCATTATGTTCAT
GGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A857A4N5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A857A4E1 |