Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 4283793..4284406 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag FOC58_RS20150 Protein ID WP_003407786.1
Coordinates 4284002..4284406 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag FOC58_RS20145 Protein ID WP_009935474.1
Coordinates 4283793..4283996 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS20115 4279198..4279578 + 381 WP_003407768.1 fumarate reductase subunit C -
FOC58_RS20120 4279575..4279952 + 378 WP_003407771.1 fumarate reductase subunit FrdD -
FOC58_RS20125 4280020..4280628 + 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
FOC58_RS20130 4280812..4281960 + 1149 Protein_3933 MMPL family transporter -
FOC58_RS20135 4281970..4282416 + 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
FOC58_RS20140 4282451..4283740 + 1290 WP_016719220.1 threonine ammonia-lyase -
FOC58_RS20145 4283793..4283996 + 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FOC58_RS20150 4284002..4284406 + 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
FOC58_RS20155 4284423..4286165 - 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
FOC58_RS20160 4286158..4288455 - 2298 WP_003407790.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T143999 WP_003407786.1 NZ_CP046309:4284002-4284406 [Mycobacterium tuberculosis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

>T143999 NZ_CP061563:6120-6401 [Acinetobacter seifertii]
ATGGCTATTAAACTTCGCAAATGGGACAGTGCTGAGCATCTTAAAACAGAAGAAGATATGCAGGCTTACTTACAAGTATG
TATTGAAGAATCTAATGGTGATGCCGCATTCATTGCTAAAGCTTTAGGTAACATTGCTAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGTCTAGGCCGAGAAAGTCTTTACAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACGGTG
ATTAAAGTTGTAAAAGCACTGAATTTGCGCTTAGCAATTTAA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT143999 WP_009935474.1 NZ_CP046309:4283793-4283996 [Mycobacterium tuberculosis]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp

>AT143999 NZ_CP061563:5817-6119 [Acinetobacter seifertii]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTCACCAAGTTAAAAGACCAACAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAACCAGTTGGTGAAGGTGTCTCTGAATTACGTTTCT
TCTTTGGACCAGGCTATAGGATTTACTACTGCAAACAAGGGCAAAGGGTTGTTATTCTTTTATCAGGTGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTGCAATTGGCACAAGATTTAGAGGAGGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References