Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4204724..4205340 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag FOC58_RS19795 Protein ID WP_003407593.1
Coordinates 4205023..4205340 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag FOC58_RS19790 Protein ID WP_003900349.1
Coordinates 4204724..4205026 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS19780 4200610..4202457 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
FOC58_RS19785 4202458..4204710 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
FOC58_RS19790 4204724..4205026 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
FOC58_RS19795 4205023..4205340 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
FOC58_RS19800 4205337..4206341 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
FOC58_RS19805 4206394..4207683 + 1290 WP_003407599.1 serine hydrolase -
FOC58_RS19810 4207756..4208529 - 774 WP_003912632.1 class I SAM-dependent methyltransferase -
FOC58_RS19815 4208587..4208799 - 213 WP_003898900.1 dodecin family protein -
FOC58_RS21090 4208809..4209033 - 225 WP_160522526.1 NUDIX domain-containing protein -
FOC58_RS19825 4209303..4210331 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T143998 WP_003407593.1 NZ_CP046309:4205023-4205340 [Mycobacterium tuberculosis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T143998 NZ_CP061563:5817-6119 [Acinetobacter seifertii]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTCACCAAGTTAAAAGACCAACAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAACCAGTTGGTGAAGGTGTCTCTGAATTACGTTTCT
TCTTTGGACCAGGCTATAGGATTTACTACTGCAAACAAGGGCAAAGGGTTGTTATTCTTTTATCAGGTGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTGCAATTGGCACAAGATTTAGAGGAGGAGCTATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT143998 WP_003900349.1 NZ_CP046309:4204724-4205026 [Mycobacterium tuberculosis]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT143998 NZ_CP061563:6120-6401 [Acinetobacter seifertii]
ATGGCTATTAAACTTCGCAAATGGGACAGTGCTGAGCATCTTAAAACAGAAGAAGATATGCAGGCTTACTTACAAGTATG
TATTGAAGAATCTAATGGTGATGCCGCATTCATTGCTAAAGCTTTAGGTAACATTGCTAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGTCTAGGCCGAGAAAGTCTTTACAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACGGTG
ATTAAAGTTGTAAAAGCACTGAATTTGCGCTTAGCAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References