Detailed information of TA system TA143995

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3903647..3904206
• Replicon: chromosome
• Accession: NZ_CP046309
• Organism: Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: FOC58_RS18470
• Protein ID: WP_003898789.1
• Coordinates: 3903647..3903940 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: FOC58_RS18475
• Protein ID: WP_003406322.1
• Coordinates: 3903937..3904206 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC58_RS18445	3899241..3899501	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
FOC58_RS18450	3899498..3899929	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
FOC58_RS18455	3899952..3901639	-	1688	Protein_3603	PE family protein	-
FOC58_RS18460	3901819..3902679	+	861	WP_003900301.1	hypothetical protein	-
FOC58_RS18465	3902760..3903590	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FOC58_RS18470	3903647..3903940	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
FOC58_RS18475	3903937..3904206	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FOC58_RS18480	3904319..3908014	-	3696	WP_003406323.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
FOC58_RS18485	3908156..3908944	-	789	WP_003406325.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T143995 WP_003898789.1 NZ_CP046309:c3903940-3903647 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T143995 NZ_CP061550:475279-475668 [Acinetobacter seifertii]
TTGGTCAACCAATTGAATTTTAAACTGAAATATAGCCGTTTCTCGATTATATTTCAGTTTTTTATTGGCCTGGGTTTAGC
AGCTCTGTTTTATCAGTTGATACCAATACTCTGGTGGTTGGTTGCGGTCTGTTTATTATTTATAAGTTTTATTTTCTTTT
TAAAACGACCACAGCTTGCTCAAATTGCTTATTTAGATCAGAAATTATGGTCACTTAGCTTTCATTCAGAACAAACCATT
TCTCGTGTAGAAATTTTAAAAATAATTGATTATCAGATTTTCGTAGTGGTCTATTTTGAGGGTGATAAAACATTAACTTC
TGTTATTTGGTTTGATCAAATGTCCTTATCTCAATGGAAACAGCTTAAGACTTTAGAAAAATTCTATTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT143995 WP_003406322.1 NZ_CP046309:c3904206-3903937 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT143995 NZ_CP061550:475027-475272 [Acinetobacter seifertii]
ATGACCTTGGAAGAACGTAAAGTAGTTTATCGCGCACGCCGCGGTTTAAAGGAAATTGATGTCTATTTTGACCCGTATGT
GAAAAATTATTATTTAAAGGCAGATCCAGCAGAAAAAGCATTGTTTGCTGAATTAGTAGAGCAGGAAGATCCTGATTTAC
TTGACTGGTTTATGGAAGTATCTGAACCGCCGCGTACAGAATTACGTGATTTTATTCATAAATTAAAGCATTATGTTCAT
GGCTGA

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2