Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3899241..3899929 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag FOC58_RS18450 Protein ID WP_003406304.1
Coordinates 3899498..3899929 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag FOC58_RS18445 Protein ID WP_003406302.1
Coordinates 3899241..3899501 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS18425 3894818..3895642 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
FOC58_RS18430 3895647..3896828 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
FOC58_RS18435 3896905..3898005 - 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
FOC58_RS18440 3898176..3899165 + 990 WP_003406301.1 malate dehydrogenase -
FOC58_RS18445 3899241..3899501 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
FOC58_RS18450 3899498..3899929 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC58_RS18455 3899952..3901639 - 1688 Protein_3603 PE family protein -
FOC58_RS18460 3901819..3902679 + 861 WP_003900301.1 hypothetical protein -
FOC58_RS18465 3902760..3903590 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
FOC58_RS18470 3903647..3903940 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
FOC58_RS18475 3903937..3904206 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T143994 WP_003406304.1 NZ_CP046309:3899498-3899929 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

>T143994 NZ_CP061539:c2380432-2380178 [Rothia terrae]
ATGAAAACACTGACATATACGGAATCTCGCGCGCGTTACGCAGAGGTCCTCGATTCGGTAGTGAATGATTGTGAAGAAGT
GGTGGTGACCCGCGCAGGACGCGAGCCAGCGGTCATCCTGTCATTGGCGGAGTACGAATCGTTGAAAGAAACCGCCTACC
TCCTGCGCTCTCCCGTCAACGCGCGTCGTCTTTTTGATTCCATTAGCGAGCTGGAAAATGATGGTGGCGCTGAACGGGAT
CTACTCGAAGACTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT143994 WP_003406302.1 NZ_CP046309:3899241-3899501 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp

>AT143994 NZ_CP061539:c2380175-2379918 [Rothia terrae]
ATGAAAATTGTGTGGAGCGAGAACGCCTGGGAAGACTATCTGTGGTGGCAGGGGCAGGATCGCAGGGTTCTCAAACGTAT
CAATCTGCTTATTAAAGATATTCAGCGCAATGGGAACGAGGGGATAGGCAAGCCAGAGGCTTTGCGTAATAATCTCTCGG
GGTATTGGTCGCGCAGGATCACTAAGGAGCACAGAATCGTCTATAAAATCGTCGACGATTCCATTCGCATTGCCGCGGTG
CGCTACCACTACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References