Detailed information of TA system TA143993

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 3754437..3755005
• Replicon: chromosome
• Accession: NZ_CP046309
• Organism: Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TH08
• Locus tag: FOC58_RS17790
• Protein ID: WP_003405865.1
• Coordinates: 3754631..3755005 (+)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TH07
• Locus tag: FOC58_RS17785
• Protein ID: WP_003405863.1
• Coordinates: 3754437..3754634 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC58_RS17765	3750478..3751116	-	639	WP_003898730.1	lipid droplet-associated protein	-
FOC58_RS17770	3751206..3752213	+	1008	WP_015629829.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
FOC58_RS17775	3752230..3753213	-	984	WP_003898731.1	hypothetical protein	-
FOC58_RS17780	3753276..3754349	+	1074	WP_003898732.1	redox-regulated ATPase YchF	-
FOC58_RS17785	3754437..3754634	+	198	WP_003405863.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FOC58_RS17790	3754631..3755005	+	375	WP_003405865.1	type II toxin-antitoxin system VapC family toxin	Toxin
FOC58_RS17795	3755208..3755906	+	699	WP_016719357.1	hypothetical protein	-
FOC58_RS17800	3756024..3756209	+	186	WP_003901093.1	hypothetical protein	-
FOC58_RS17805	3756136..3756411	-	276	WP_003405867.1	hypothetical protein	-
FOC58_RS17810	3756654..3756977	+	324	WP_003405871.1	antibiotic biosynthesis monooxygenase	-
FOC58_RS17815	3756992..3757702	-	711	WP_003911399.1	hypothetical protein	-
FOC58_RS21065	3757724..3757933	+	210	WP_003911400.1	hypothetical protein	-
FOC58_RS17820	3757885..3758592	-	708	Protein_3480	adenylate/guanylate cyclase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-111)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13444.56 Da
• Isoelectric Point: 5.1881

>T143993 WP_003405865.1 NZ_CP046309:3754631-3755005 [Mycobacterium tuberculosis]
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS

Nucleotide

• Length: 375 bp

>T143993 NZ_CP061539:c2380175-2379918 [Rothia terrae]
ATGAAAATTGTGTGGAGCGAGAACGCCTGGGAAGACTATCTGTGGTGGCAGGGGCAGGATCGCAGGGTTCTCAAACGTAT
CAATCTGCTTATTAAAGATATTCAGCGCAATGGGAACGAGGGGATAGGCAAGCCAGAGGCTTTGCGTAATAATCTCTCGG
GGTATTGGTCGCGCAGGATCACTAAGGAGCACAGAATCGTCTATAAAATCGTCGACGATTCCATTCGCATTGCCGCGGTG
CGCTACCACTACGAGTAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 6973.03 Da
• Isoelectric Point: 11.7327

>AT143993 WP_003405863.1 NZ_CP046309:3754437-3754634 [Mycobacterium tuberculosis]
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR

Nucleotide

• Length: 198 bp

>AT143993 NZ_CP061539:c2380432-2380178 [Rothia terrae]
ATGAAAACACTGACATATACGGAATCTCGCGCGCGTTACGCAGAGGTCCTCGATTCGGTAGTGAATGATTGTGAAGAAGT
GGTGGTGACCCGCGCAGGACGCGAGCCAGCGGTCATCCTGTCATTGGCGGAGTACGAATCGTTGAAAGAAACCGCCTACC
TCCTGCGCTCTCCCGTCAACGCGCGTCGTCTTTTTGATTCCATTAGCGAGCTGGAAAATGATGGTGGCGCTGAACGGGAT
CTACTCGAAGACTAG

Structures

Toxin

• AlphaFold DB: G0TH08

Antitoxin

• AlphaFold DB: G0TH07