Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3745681..3746312 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag FOC58_RS17735 Protein ID WP_003405820.1
Coordinates 3745681..3745992 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag FOC58_RS17740 Protein ID WP_003405836.1
Coordinates 3745992..3746312 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T143992 WP_003405820.1 NZ_CP046309:c3745992-3745681 [Mycobacterium tuberculosis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T143992 NZ_CP061539:177881-178198 [Rothia terrae]
ATGCGCGAAATATGTCTGGTGCACCTCGATAAGACCCGCCCTGCTCTAGTTCTGACCCGCGAGCCAACTCGATTTGTGAT
GTCCAAAATAACAATCGCCCCTATCACTTCAACGGTGAAGGGGCTTTCAAGCGAGGTTTTGCTAGGTTCTCAGAATGGTC
TTAACCATGAGTGTGTTGCGTCAATCGATAACATTTTGACTGTTCCCGCTTCAGCTTTAGGGCGCACCATCGGCTACTTA
ACAGAGACTCAAGAGAAAGACTTGACGCGTGCTGTCGTTTTGGCTTTTGACCTGCGGGTTCCTTTATCTGAAGGATAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT143992 WP_003405836.1 NZ_CP046309:c3746312-3745992 [Mycobacterium tuberculosis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp

>AT143992 NZ_CP061539:177642-177872 [Rothia terrae]
ATGACTACTCAAATTGCCGTTCGCTTGCCCGATGACCTGGTTGAGTTTCTCGACTCTGCAGTCGCACATGGTGAGGCCCC
GAGCCGTGCCGCTATTGTGGCTGAGGCACTCGAGCAAGAACGTCGTAAATACGCCGCACGAGCCGATACTCAAATTCTTC
AAGAACAGGGCACTGAAGATGATCTCGACGATTTAGTTGCGTGGACTGCTTCATCGGCAGTTATTGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References