Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3745681..3746312 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag FOC58_RS17735 Protein ID WP_003405820.1
Coordinates 3745681..3745992 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag FOC58_RS17740 Protein ID WP_003405836.1
Coordinates 3745992..3746312 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS17715 3741162..3742586 - 1425 WP_003405805.1 class II fumarate hydratase -
FOC58_RS17720 3742617..3743705 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
FOC58_RS17725 3743761..3744405 + 645 WP_003915494.1 DUF4245 domain-containing protein -
FOC58_RS17730 3744412..3745569 - 1158 WP_003898727.1 AI-2E family transporter -
FOC58_RS17735 3745681..3745992 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
FOC58_RS17740 3745992..3746312 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
FOC58_RS17745 3746322..3747847 + 1526 Protein_3464 carboxylesterase/lipase family protein -
FOC58_RS17750 3747865..3748977 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
FOC58_RS17755 3748987..3749244 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
FOC58_RS17760 3749234..3750481 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
FOC58_RS17765 3750478..3751116 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T143992 WP_003405820.1 NZ_CP046309:c3745992-3745681 [Mycobacterium tuberculosis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T143992 NZ_CP061539:177881-178198 [Rothia terrae]
ATGCGCGAAATATGTCTGGTGCACCTCGATAAGACCCGCCCTGCTCTAGTTCTGACCCGCGAGCCAACTCGATTTGTGAT
GTCCAAAATAACAATCGCCCCTATCACTTCAACGGTGAAGGGGCTTTCAAGCGAGGTTTTGCTAGGTTCTCAGAATGGTC
TTAACCATGAGTGTGTTGCGTCAATCGATAACATTTTGACTGTTCCCGCTTCAGCTTTAGGGCGCACCATCGGCTACTTA
ACAGAGACTCAAGAGAAAGACTTGACGCGTGCTGTCGTTTTGGCTTTTGACCTGCGGGTTCCTTTATCTGAAGGATAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT143992 WP_003405836.1 NZ_CP046309:c3746312-3745992 [Mycobacterium tuberculosis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp

>AT143992 NZ_CP061539:177642-177872 [Rothia terrae]
ATGACTACTCAAATTGCCGTTCGCTTGCCCGATGACCTGGTTGAGTTTCTCGACTCTGCAGTCGCACATGGTGAGGCCCC
GAGCCGTGCCGCTATTGTGGCTGAGGCACTCGAGCAAGAACGTCGTAAATACGCCGCACGAGCCGATACTCAAATTCTTC
AAGAACAGGGCACTGAAGATGATCTCGACGATTTAGTTGCGTGGACTGCTTCATCGGCAGTTATTGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References