Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3269442..3270130 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag FOC58_RS15365 Protein ID WP_003403386.1
Coordinates 3269442..3269879 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O06777
Locus tag FOC58_RS15370 Protein ID WP_003911263.1
Coordinates 3269876..3270130 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS15335 3265693..3266703 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
FOC58_RS15340 3267091..3267474 - 384 WP_015629650.1 hypothetical protein -
FOC58_RS15345 3267569..3267724 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
FOC58_RS15350 3267800..3268516 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
FOC58_RS15355 3268792..3269100 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
FOC58_RS15360 3269087..3269332 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
FOC58_RS15365 3269442..3269879 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC58_RS15370 3269876..3270130 - 255 WP_003911263.1 antitoxin VapB7 Antitoxin
FOC58_RS15375 3270244..3272607 + 2364 WP_003403397.1 arylsulfatase AtsD -
FOC58_RS15380 3272670..3272996 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FOC58_RS15385 3272908..3273246 + 339 WP_003403405.1 PIN domain-containing protein -
FOC58_RS15390 3273243..3273416 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T143988 WP_003403386.1 NZ_CP046309:c3269879-3269442 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T143988 NZ_CP061530:c4255926-4255819 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTTGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9450.99 Da        Isoelectric Point: 11.7073

>AT143988 WP_003911263.1 NZ_CP046309:c3270130-3269876 [Mycobacterium tuberculosis]
MSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALR
ARRG

Download         Length: 255 bp

>AT143988 NZ_CP061530:4255974-4256040 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JQG1

References