Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3268792..3269332 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name mazF Uniprot ID P9WII0
Locus tag FOC58_RS15355 Protein ID WP_003403376.1
Coordinates 3268792..3269100 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag FOC58_RS15360 Protein ID WP_003403381.1
Coordinates 3269087..3269332 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS15330 3264107..3265612 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
FOC58_RS15335 3265693..3266703 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
FOC58_RS15340 3267091..3267474 - 384 WP_015629650.1 hypothetical protein -
FOC58_RS15345 3267569..3267724 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
FOC58_RS15350 3267800..3268516 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
FOC58_RS15355 3268792..3269100 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FOC58_RS15360 3269087..3269332 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
FOC58_RS15365 3269442..3269879 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
FOC58_RS15370 3269876..3270130 - 255 WP_003911263.1 antitoxin VapB7 -
FOC58_RS15375 3270244..3272607 + 2364 WP_003403397.1 arylsulfatase AtsD -
FOC58_RS15380 3272670..3272996 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FOC58_RS15385 3272908..3273246 + 339 WP_003403405.1 PIN domain-containing protein -
FOC58_RS15390 3273243..3273416 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-101)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11320.10 Da        Isoelectric Point: 11.6554

>T143986 WP_003403376.1 NZ_CP046309:c3269100-3268792 [Mycobacterium tuberculosis]
MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGLVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRR
ITRLSPARLHEACQTLRASTGC

Download         Length: 309 bp

>T143986 NZ_CP061530:c3805642-3805328 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT143986 WP_003403381.1 NZ_CP046309:c3269332-3269087 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT143986 NZ_CP061530:c3805331-3804915 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSE5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References