143983

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3229984..3230633 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag FOC58_RS15155 Protein ID WP_003403236.1
Coordinates 3230238..3230633 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag FOC58_RS15150 Protein ID WP_003403235.1
Coordinates 3229984..3230238 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS15125 3225110..3225805 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
FOC58_RS15130 3225802..3226293 + 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
FOC58_RS15135 3226290..3227381 + 1092 WP_003900977.1 galactokinase -
FOC58_RS15140 3227776..3228840 + 1065 WP_003898532.1 hypothetical protein -
FOC58_RS15145 3228944..3229891 + 948 WP_003403232.1 DUF732 domain-containing protein -
FOC58_RS15150 3229984..3230238 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
FOC58_RS15155 3230238..3230633 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
FOC58_RS15160 3230727..3231467 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
FOC58_RS15165 3231599..3231859 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FOC58_RS15170 3231856..3232263 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
FOC58_RS15175 3232335..3233486 - 1152 WP_003403248.1 FIST C-terminal domain-containing protein -
FOC58_RS15180 3233579..3235306 - 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T143983 WP_003403236.1 NZ_CP046309:3230238-3230633 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T143983 NZ_CP061530:c3475192-3474857 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT143983 WP_003403235.1 NZ_CP046309:3229984-3230238 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT143983 NZ_CP061530:c3475440-3475192 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC2

References