Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3224356..3224981 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag FOC58_RS15120 Protein ID WP_003403218.1
Coordinates 3224580..3224981 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag FOC58_RS15115 Protein ID WP_003403213.1
Coordinates 3224356..3224583 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS15085 3219535..3219756 - 222 WP_003898525.1 DUF4926 domain-containing protein -
FOC58_RS15090 3219898..3220503 + 606 WP_003898526.1 hypothetical protein -
FOC58_RS15095 3220522..3223089 - 2568 WP_031647101.1 SEC-C domain-containing protein -
FOC58_RS15100 3223173..3223922 + 750 WP_003898528.1 hypothetical protein -
FOC58_RS15105 3223919..3224161 + 243 WP_003403210.1 hypothetical protein -
FOC58_RS15115 3224356..3224583 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
FOC58_RS15120 3224580..3224981 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
FOC58_RS15125 3225110..3225805 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
FOC58_RS15130 3225802..3226293 + 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
FOC58_RS15135 3226290..3227381 + 1092 WP_003900977.1 galactokinase -
FOC58_RS15140 3227776..3228840 + 1065 WP_003898532.1 hypothetical protein -
FOC58_RS15145 3228944..3229891 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T143982 WP_003403218.1 NZ_CP046309:3224580-3224981 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T143982 NZ_CP061530:c2682266-2682015 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT143982 WP_003403213.1 NZ_CP046309:3224356-3224583 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT143982 NZ_CP061530:c2682018-2681764 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References