Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3216818..3217461 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag FOC58_RS15060 Protein ID WP_003403187.1
Coordinates 3217060..3217461 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag FOC58_RS15055 Protein ID WP_003403184.1
Coordinates 3216818..3217063 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS15020 3212098..3212628 - 531 WP_003917320.1 two component system sensor kinase HK2 -
FOC58_RS15025 3212612..3213307 - 696 WP_003918099.1 two-component system response regulator TcrA -
FOC58_RS15030 3213430..3213741 + 312 WP_003403164.1 hypothetical protein -
FOC58_RS15035 3213813..3214763 + 951 WP_003900184.1 DUF1259 domain-containing protein -
FOC58_RS15040 3215004..3215588 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
FOC58_RS15045 3215590..3216300 + 711 Protein_2943 transposase -
FOC58_RS15050 3216303..3216773 + 471 WP_003898523.1 hypothetical protein -
FOC58_RS15055 3216818..3217063 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FOC58_RS15060 3217060..3217461 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC58_RS15070 3217849..3218016 - 168 WP_077385191.1 DUF3800 domain-containing protein -
FOC58_RS15075 3218049..3218246 - 198 WP_003403191.1 hypothetical protein -
FOC58_RS15080 3218326..3219483 - 1158 WP_003898524.1 hypothetical protein -
FOC58_RS15085 3219535..3219756 - 222 WP_003898525.1 DUF4926 domain-containing protein -
FOC58_RS15090 3219898..3220503 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T143981 WP_003403187.1 NZ_CP046309:3217060-3217461 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T143981 NZ_CP061530:c2682018-2681764 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT143981 WP_003403184.1 NZ_CP046309:3216818-3217063 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT143981 NZ_CP061530:c2682266-2682015 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References