Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 3208413..3209059 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag FOC58_RS14990 Protein ID WP_003403122.1
Coordinates 3208413..3208805 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag FOC58_RS14995 Protein ID WP_003403125.1
Coordinates 3208802..3209059 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS14975 3204075..3205601 + 1527 WP_003403112.1 virulence factor Mce family protein -
FOC58_RS14980 3205664..3206806 + 1143 WP_003911253.1 virulence factor Mce family protein -
FOC58_RS14985 3206811..3208361 + 1551 WP_003403119.1 MCE family protein -
FOC58_RS14990 3208413..3208805 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
FOC58_RS14995 3208802..3209059 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
FOC58_RS15000 3209242..3210477 - 1236 WP_003403128.1 ATP-binding protein -
FOC58_RS15005 3210728..3211141 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
FOC58_RS15010 3211138..3211374 - 237 WP_003403139.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
FOC58_RS15015 3211478..3211984 - 507 WP_003900973.1 two component system sensor kinase HK1 -
FOC58_RS15020 3212098..3212628 - 531 WP_003917320.1 two component system sensor kinase HK2 -
FOC58_RS15025 3212612..3213307 - 696 WP_003918099.1 two-component system response regulator TcrA -
FOC58_RS15030 3213430..3213741 + 312 WP_003403164.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T143979 WP_003403122.1 NZ_CP046309:c3208805-3208413 [Mycobacterium tuberculosis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

>T143979 NZ_CP061530:c2158750-2158463 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT143979 WP_003403125.1 NZ_CP046309:c3209059-3208802 [Mycobacterium tuberculosis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp

>AT143979 NZ_CP061530:c2158989-2158750 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References