143976

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 2956495..2957506 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag FOC58_RS13780 Protein ID WP_003401859.1
Coordinates 2956495..2957088 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag FOC58_RS13785 Protein ID WP_003401860.1
Coordinates 2957117..2957506 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS13760 2952144..2953526 + 1383 WP_155936546.1 magnesium transporter -
FOC58_RS13765 2953538..2954572 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
FOC58_RS13770 2954668..2955351 + 684 WP_003401857.1 VTT domain-containing protein -
FOC58_RS13775 2955340..2956470 - 1131 WP_003401858.1 hypothetical protein -
FOC58_RS13780 2956495..2957088 - 594 WP_003401859.1 zeta toxin family protein Toxin
FOC58_RS13785 2957117..2957506 - 390 WP_003401860.1 hypothetical protein Antitoxin
FOC58_RS13790 2957587..2958798 - 1212 WP_003401861.1 VWA domain-containing protein -
FOC58_RS13795 2958804..2959406 - 603 WP_003898417.1 SRPBCC family protein -
FOC58_RS13800 2959420..2960316 - 897 WP_003898418.1 MoxR family ATPase -
FOC58_RS13805 2960313..2960906 - 594 WP_003401864.1 NTP transferase domain-containing protein -
FOC58_RS13810 2960903..2961658 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T143976 WP_003401859.1 NZ_CP046309:c2957088-2956495 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T143976 NZ_CP061530:c1923889-1923695 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT143976 WP_003401860.1 NZ_CP046309:c2957506-2957117 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT143976 NZ_CP061530:1923518-1923696 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References