Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 1868077..1868606 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag FOC58_RS08910 Protein ID WP_003417760.1
Coordinates 1868349..1868606 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag FOC58_RS08905 Protein ID WP_003417757.1
Coordinates 1868077..1868352 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS20925 1864875..1866312 - 1438 Protein_1735 FAD-binding oxidoreductase -
FOC58_RS08890 1866415..1866804 + 390 WP_003417745.1 DUF732 domain-containing protein -
FOC58_RS08895 1866818..1867111 - 294 WP_003417749.1 DUF3017 domain-containing protein -
FOC58_RS08900 1867108..1867953 - 846 WP_155936555.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
FOC58_RS08905 1868077..1868352 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
FOC58_RS08910 1868349..1868606 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
FOC58_RS08915 1868648..1869838 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
FOC58_RS08920 1869955..1870322 + 368 Protein_1742 FHA domain-containing protein -
FOC58_RS08925 1870319..1870870 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
FOC58_RS08930 1870877..1871458 - 582 WP_003417769.1 ATP/GTP-binding protein -
FOC58_RS08935 1871439..1871807 - 369 WP_003417772.1 DUF742 domain-containing protein -
FOC58_RS08940 1871785..1872177 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T143969 WP_003417760.1 NZ_CP046309:1868349-1868606 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T143969 NZ_CP061530:294040-294213 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT143969 WP_003417757.1 NZ_CP046309:1868077-1868352 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT143969 NZ_CP061530:293716-294012 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGACTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References