Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1800403..1801077 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag FOC58_RS08690 Protein ID WP_003417282.1
Coordinates 1800403..1800831 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag FOC58_RS08695 Protein ID WP_003417286.1
Coordinates 1800835..1801077 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS08665 1796225..1796626 - 402 WP_003417264.1 cytidine deaminase -
FOC58_RS08670 1796767..1797201 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
FOC58_RS08675 1797198..1797632 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
FOC58_RS08680 1797761..1799533 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
FOC58_RS08685 1799533..1800324 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
FOC58_RS08690 1800403..1800831 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC58_RS08695 1800835..1801077 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
FOC58_RS08700 1801199..1801813 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
FOC58_RS08705 1801810..1802475 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
FOC58_RS08710 1802476..1803009 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
FOC58_RS08715 1803006..1803380 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
FOC58_RS08720 1803477..1804541 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T143968 WP_003417282.1 NZ_CP046309:c1800831-1800403 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T143968 NZ_CP061527:c3810650-3810300 [Shigella dysenteriae]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTTGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT143968 WP_003417286.1 NZ_CP046309:c1801077-1800835 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT143968 NZ_CP061527:c3810895-3810644 [Shigella dysenteriae]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTATG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCTACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References