Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1266607..1267155 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag FOC58_RS06240 Protein ID WP_003414602.1
Coordinates 1266892..1267155 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag FOC58_RS06235 Protein ID WP_003414599.1
Coordinates 1266607..1266888 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS06210 1262230..1263087 - 858 WP_016719566.1 type I methionyl aminopeptidase -
FOC58_RS06215 1263129..1263713 - 585 WP_003414585.1 DUF1707 domain-containing protein -
FOC58_RS06220 1263817..1264065 + 249 WP_003913411.1 antitoxin VapB23 -
FOC58_RS06225 1264062..1264442 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
FOC58_RS06230 1264524..1266335 - 1812 WP_003414596.1 penicillin-binding protein -
FOC58_RS06235 1266607..1266888 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
FOC58_RS06240 1266892..1267155 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOC58_RS06245 1267528..1268382 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
FOC58_RS06250 1268438..1269601 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
FOC58_RS06255 1269618..1270832 - 1215 WP_003414610.1 zinc metalloprotease Rip -
FOC58_RS06260 1270840..1272081 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T143965 WP_003414602.1 NZ_CP046309:1266892-1267155 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T143965 NZ_CP061527:3363969-3364247 [Shigella dysenteriae]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAGG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGCTCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT143965 WP_003414599.1 NZ_CP046309:1266607-1266888 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT143965 NZ_CP061527:3363706-3363966 [Shigella dysenteriae]
ATGGCTGCAAATGCATTTGTTCGTGCCCGAATCGATGAGGATTTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGGTGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References