Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1199456..1200026 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag FOC58_RS05890 Protein ID WP_003414166.1
Coordinates 1199456..1199812 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag FOC58_RS05895 Protein ID WP_003901465.1
Coordinates 1199796..1200026 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS05870 1194908..1196596 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
FOC58_RS05875 1196600..1196926 - 327 WP_003414157.1 hypothetical protein -
FOC58_RS05880 1197099..1197686 + 588 WP_031665864.1 DUF3558 family protein -
FOC58_RS05885 1197705..1199354 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
FOC58_RS05890 1199456..1199812 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
FOC58_RS05895 1199796..1200026 - 231 WP_003901465.1 antitoxin MazE Antitoxin
FOC58_RS05900 1200069..1201112 - 1044 WP_016720604.1 DUF2293 domain-containing protein -
FOC58_RS05905 1201303..1201578 + 276 WP_003911993.1 DUF1778 domain-containing protein -
FOC58_RS05910 1201754..1202008 - 255 WP_155936531.1 hypothetical protein -
FOC58_RS05915 1202156..1202560 + 405 WP_003414181.1 hypothetical protein -
FOC58_RS05920 1202557..1202748 + 192 WP_003414184.1 hypothetical protein -
FOC58_RS05925 1202812..1204100 + 1289 Protein_1164 transposase family protein -
FOC58_RS05930 1204334..1204591 + 258 WP_003899489.1 hypothetical protein -
FOC58_RS05935 1204696..1205007 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T143962 WP_003414166.1 NZ_CP046309:c1199812-1199456 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

>T143962 NZ_CP061527:c2494859-2494756 [Shigella dysenteriae]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT143962 WP_003901465.1 NZ_CP046309:c1200026-1199796 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT143962 NZ_CP061527:2494756-2494989 [Shigella dysenteriae]
AAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATA
AAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGTTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
PDB 7DU5
PDB 6KYT
AlphaFold DB A0A7U4FBW3

References