Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1159459..1160138 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name vapC Uniprot ID P9WF90
Locus tag FOC58_RS05665 Protein ID WP_003414059.1
Coordinates 1159459..1159875 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TF64
Locus tag FOC58_RS05670 Protein ID WP_003414061.1
Coordinates 1159872..1160138 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS05645 1155511..1156413 - 903 WP_003900564.1 4-hydroxy-tetrahydrodipicolinate synthase -
FOC58_RS05650 1156482..1157234 - 753 WP_003899465.1 FAD-dependent thymidylate synthase -
FOC58_RS05655 1157478..1157753 - 276 WP_003414055.1 type I restriction endonuclease subunit S -
FOC58_RS05660 1157750..1159372 - 1623 WP_015630537.1 type I restriction-modification system subunit M -
FOC58_RS05665 1159459..1159875 - 417 WP_003414059.1 type II toxin-antitoxin system toxin ribonuclease C21 Toxin
FOC58_RS05670 1159872..1160138 - 267 WP_003414061.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FOC58_RS05675 1160164..1160559 - 396 WP_003414064.1 type II toxin-antitoxin system VapC family toxin -
FOC58_RS05680 1160556..1160825 - 270 WP_003414066.1 type II toxin-antitoxin system VapB family antitoxin -
FOC58_RS05685 1160835..1161929 - 1095 WP_015630539.1 restriction endonuclease subunit S -
FOC58_RS05690 1161926..1162345 - 420 WP_003414070.1 winged helix-turn-helix domain-containing protein -
FOC58_RS05695 1162419..1162898 - 480 WP_003414073.1 dihydrofolate reductase -
FOC58_RS05700 1162969..1163769 - 801 WP_003911953.1 thymidylate synthase -
FOC58_RS05705 1163925..1164662 + 738 WP_003414079.1 dienelactone hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(16-56)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15773.00 Da        Isoelectric Point: 7.1294

>T143960 WP_003414059.1 NZ_CP046309:c1159875-1159459 [Mycobacterium tuberculosis]
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA

Download         Length: 417 bp

>T143960 NZ_CP061527:2433018-2433125 [Shigella dysenteriae]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9493.77 Da        Isoelectric Point: 7.2783

>AT143960 WP_003414061.1 NZ_CP046309:c1160138-1159872 [Mycobacterium tuberculosis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA

Download         Length: 267 bp

>AT143960 NZ_CP061527:c2432971-2432905 [Shigella dysenteriae]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5SV2

Antitoxin

Source ID Structure
AlphaFold DB G0TF64

References