Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1019201..1019915 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag FOC58_RS04835 Protein ID WP_003413460.1
Coordinates 1019475..1019915 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag FOC58_RS04830 Protein ID WP_003413456.1
Coordinates 1019201..1019488 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS04795 1014624..1014860 + 237 Protein_944 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
FOC58_RS04800 1014865..1015269 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
FOC58_RS04805 1015486..1016106 + 621 WP_003413441.1 DUF4178 domain-containing protein -
FOC58_RS04810 1016117..1016611 + 495 WP_003413444.1 DUF2617 family protein -
FOC58_RS04815 1016608..1017039 + 432 WP_003899390.1 DUF4247 domain-containing protein -
FOC58_RS04820 1017064..1017522 + 459 WP_003413451.1 DUF350 domain-containing protein -
FOC58_RS04825 1017519..1019090 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
FOC58_RS04830 1019201..1019488 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
FOC58_RS04835 1019475..1019915 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC58_RS04840 1019936..1020691 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
FOC58_RS04845 1020824..1021420 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
FOC58_RS04850 1021428..1022273 - 846 WP_003413466.1 acyl-CoA thioesterase II -
FOC58_RS04855 1022302..1023201 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
FOC58_RS04860 1023329..1024003 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T143958 WP_003413460.1 NZ_CP046309:1019475-1019915 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T143958 NZ_CP061527:841049-841384 [Shigella dysenteriae]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT143958 WP_003413456.1 NZ_CP046309:1019201-1019488 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT143958 NZ_CP061527:840801-841049 [Shigella dysenteriae]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACTTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References