Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 958860..959497 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag FOC58_RS04570 Protein ID WP_003413180.1
Coordinates 958860..959255 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag FOC58_RS04575 Protein ID WP_003413183.1
Coordinates 959252..959497 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS04530 954263..955474 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
FOC58_RS04535 955601..956260 + 660 WP_003900846.1 LppA family lipoprotein -
FOC58_RS04540 956257..956919 + 663 WP_023643170.1 hypothetical protein -
FOC58_RS04545 956916..957194 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
FOC58_RS04550 957287..957700 + 414 WP_003413164.1 PIN domain nuclease -
FOC58_RS04555 957739..957996 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein -
FOC58_RS04560 957993..958370 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
FOC58_RS04565 958386..958760 - 375 WP_003413177.1 hypothetical protein -
FOC58_RS04570 958860..959255 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 Toxin
FOC58_RS04575 959252..959497 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 Antitoxin
FOC58_RS04580 959908..960327 - 420 WP_003413190.1 A24 family peptidase -
FOC58_RS04585 960339..961148 - 810 WP_003413193.1 shikimate dehydrogenase -
FOC58_RS04590 961145..962398 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
FOC58_RS04595 962391..962903 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T143957 WP_003413180.1 NZ_CP046309:c959255-958860 [Mycobacterium tuberculosis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

>T143957 NZ_CP061527:c654899-654492 [Shigella dysenteriae]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGTGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT143957 WP_003413183.1 NZ_CP046309:c959497-959252 [Mycobacterium tuberculosis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp

>AT143957 NZ_CP061527:c655146-654880 [Shigella dysenteriae]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCAGACC
TGTTCAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5WZ4
PDB 5WZF

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW31

References