Detailed information of TA system TA143954

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 943400..944040
• Replicon: chromosome
• Accession: NZ_CP046309
• Organism: Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ08
• Locus tag: FOC58_RS04465
• Protein ID: WP_003412970.1
• Coordinates: 943400..943819 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FOC58_RS04470
• Protein ID: WP_031647222.1
• Coordinates: 943816..944040 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC58_RS04440	938985..939707	-	723	WP_003412957.1	DUF1906 domain-containing protein	-
FOC58_RS04445	940224..940451	+	228	WP_003412960.1	type II toxin-antitoxin system VapB family antitoxin	-
FOC58_RS04450	940448..940849	+	402	WP_003412963.1	PIN domain-containing protein	-
FOC58_RS04455	940884..941804	-	921	WP_003412965.1	restriction endonuclease	-
FOC58_RS20870	942145..942390	-	246	WP_071854223.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
FOC58_RS04460	942449..943399	+	951	WP_003911916.1	Lsr2 family protein	-
FOC58_RS04465	943400..943819	-	420	WP_003412970.1	type II toxin-antitoxin system VapC family toxin	Toxin
FOC58_RS04470	943816..944040	-	225	WP_031647222.1	antitoxin VapB39	Antitoxin
FOC58_RS04475	944071..946914	-	2844	WP_003899363.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
FOC58_RS04480	946986..947387	-	402	WP_003412981.1	hypothetical protein	-
FOC58_RS04485	947387..947857	-	471	WP_003899364.1	transcription antitermination factor NusB	-
FOC58_RS04490	947860..948423	-	564	WP_003412989.1	elongation factor P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14732.70 Da
• Isoelectric Point: 6.7519

>T143954 WP_003412970.1 NZ_CP046309:c943819-943400 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Nucleotide

• Length: 420 bp

>T143954 NZ_CP061525:1088647-1088829 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8021.99 Da
• Isoelectric Point: 4.1116

>AT143954 WP_031647222.1 NZ_CP046309:c944040-943816 [Mycobacterium tuberculosis]
MRTTLRIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Nucleotide

• Length: 225 bp

>AT143954 NZ_CP061525:1088894-1089298 [Acinetobacter baumannii]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Structures

Toxin

• AlphaFold DB: G0TQ08