Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 491286..491815 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag FOC58_RS02365 Protein ID WP_003411124.1
Coordinates 491286..491603 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag FOC58_RS02370 Protein ID WP_003411127.1
Coordinates 491600..491815 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS02335 486423..487499 + 1077 WP_003411110.1 hypothetical protein -
FOC58_RS02340 487496..487777 + 282 WP_003411112.1 hypothetical protein -
FOC58_RS02345 487813..488886 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
FOC58_RS02350 488891..489421 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
FOC58_RS02355 489469..490815 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
FOC58_RS02365 491286..491603 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOC58_RS02370 491600..491815 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
FOC58_RS02375 492070..493128 + 1059 WP_003411129.1 hypothetical protein -
FOC58_RS02380 493258..493614 - 357 WP_003411130.1 hypothetical protein -
FOC58_RS02385 493709..494491 - 783 WP_031647332.1 cell wall synthesis protein Wag31 -
FOC58_RS02390 494759..495049 - 291 WP_003900476.1 YggT family protein -
FOC58_RS02395 495211..495867 - 657 WP_003411133.1 cell division protein SepF -
FOC58_RS02400 495933..496709 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T143952 WP_003411124.1 NZ_CP046309:c491603-491286 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T143952 NZ_CP061523:1252870-1253052 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT143952 WP_003411127.1 NZ_CP046309:c491815-491600 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT143952 NZ_CP061523:1253145-1253549 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References