Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 453068..453763 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag FOC58_RS02155 Protein ID WP_003410811.1
Coordinates 453068..453502 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag FOC58_RS02160 Protein ID WP_003410814.1
Coordinates 453509..453763 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS02145 449222..452263 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
FOC58_RS02150 452256..453089 + 834 WP_003899172.1 SWIM zinc finger family protein -
FOC58_RS02155 453068..453502 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC58_RS02160 453509..453763 - 255 WP_003410814.1 antitoxin Antitoxin
FOC58_RS02165 453779..454036 - 258 WP_003410816.1 hypothetical protein -
FOC58_RS02170 454956..456217 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
FOC58_RS02175 456340..456636 + 297 WP_003410820.1 PE family protein -
FOC58_RS02180 456692..457423 + 732 WP_003900467.1 PPE family protein -
FOC58_RS02185 457963..458709 - 747 WP_003901330.1 proteasome subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T143951 WP_003410811.1 NZ_CP046309:c453502-453068 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T143951 NZ_CP061523:540506-540688 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT143951 WP_003410814.1 NZ_CP046309:c453763-453509 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT143951 NZ_CP061523:540781-541185 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References