Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 314053..314951 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag FOC58_RS01540 Protein ID WP_003410001.1
Coordinates 314053..314613 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag FOC58_RS01545 Protein ID WP_003410003.1
Coordinates 314610..314951 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS01510 309222..309875 - 654 WP_003409976.1 cutinase Cfp21 -
FOC58_RS01515 309990..310220 + 231 WP_003409980.1 DUF167 domain-containing protein -
FOC58_RS01520 310305..311216 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
FOC58_RS01525 311325..311924 + 600 WP_003409989.1 L-lysine exporter -
FOC58_RS01530 312340..312768 + 429 WP_003409992.1 cellulose-binding protein -
FOC58_RS01535 312994..313533 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
FOC58_RS01540 314053..314613 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
FOC58_RS01545 314610..314951 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
FOC58_RS01550 315037..315294 + 258 WP_003410006.1 hypothetical protein -
FOC58_RS01555 315195..315530 - 336 WP_003410009.1 dehydrogenase -
FOC58_RS01560 315619..315963 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
FOC58_RS01565 315957..316205 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
FOC58_RS01570 316305..318557 - 2253 WP_016719189.1 cation transporter ATPase CptG -
FOC58_RS01575 318554..318826 - 273 WP_003410017.1 DUF1490 family protein -
FOC58_RS01580 318879..319235 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T143946 WP_003410001.1 NZ_CP046309:c314613-314053 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T143946 NZ_CP061519:1305357-1305539 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT143946 WP_003410003.1 NZ_CP046309:c314951-314610 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT143946 NZ_CP061519:1305632-1306036 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References